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首页> 外文期刊>Nuclear Medicine Communications >Imaging features of colorectal liver metastasis in FDG PET-CT: A retrospective correlative analysis between CT attenuation and FDG uptake
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Imaging features of colorectal liver metastasis in FDG PET-CT: A retrospective correlative analysis between CT attenuation and FDG uptake

机译：FDG PET-CT结直肠肝转移的影像学特征：CT衰减与FDG摄取之间的回顾性相关分析

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OBJECTIVES: Increasing scientific evidence supports the use of fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) in the staging of colorectal carcinoma. A detailed and accurate characterization of tumor biology and imaging characteristics is therefore of paramount importance. The aim of our study was to determine whether CT attenuation, in Hounsfield units, was correlated with FDG uptake in colorectal liver metastasis. METHODS: The clinical and imaging data of patients from our institution with histologically proven colorectal carcinoma who were referred for PET/CT staging were reviewed. For the purpose of our study, we included only those patients who had undergone dual-time-point imaging. A total of 20 patients with 62 hepatic secondaries were identified. The perlesional CT attenuation (in Hounsfield units), FDG uptake (in standardized uptake values SUV60 and SUV120), and size (in cm) were determined. Correlation analysis using the Spearman rank correlation coefficient was carried out. RESULTS: A statistically significant positive relationship was observed between perlesional CT attenuation and SUV60 (r=0.433, P=0.0004). A similar significant positive relationship was shown between perlesional CT attenuation and SUV120 (r=0.414, P=0.0008). CONCLUSION: Our study suggested that, in colorectal liver metastasis, FDG uptake was positively correlated with CT attenuation. If a lesion appeared to be indeterminate because of apparently low FDG avidity, internal content must be taken into consideration to minimize misdiagnosis and false negatives. We proposed that such a relationship may be due to the mucinous contents of colorectal liver metastasis or degree of tumor necrosis. Further research, particularly on quantification of the extent of mucin production and tumor necrosis, may allow a more precise relationship to be drawn between CT attenuation and FDG uptake.
机译：目的：越来越多的科学证据支持在大肠癌分期中使用氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（FDG-PET / CT）。因此，对肿瘤生物学和影像学特征进行详细而准确的表征至关重要。我们研究的目的是确定CT衰减（以Hounsfield为单位）是否与大肠肝转移中FDG的摄取有关。方法：回顾了我院经组织学证实为结直肠癌的患者接受PET / CT分期的临床和影像学资料。为了我们的研究目的，我们仅包括接受过双重时间点成像的那些患者。总共鉴定出20例患者，其中62例为肝次生。确定了病变CT衰减（以Hounsfield单位），FDG吸收（以SUV60和SUV120的标准化吸收值）和尺寸（以cm为单位）。使用Spearman秩相关系数进行相关分析。结果：病变CT衰减与SUV60之间存在统计学意义的正相关（r = 0.433，P = 0.0004）。病变CT衰减与SUV120之间显示出相似的显着正相关（r = 0.414，P = 0.0008）。结论：我们的研究表明，在大肠肝转移中，FDG的摄取与CT衰减呈正相关。如果由于FDG亲和力明显较低而使病变似乎不确定，则必须考虑内部含量，以最大程度地减少误诊和假阴性。我们提出这种关系可能是由于结肠直肠肝转移的粘液含量或肿瘤坏死程度所致。进一步的研究，特别是对粘蛋白产生和肿瘤坏死程度的定量研究，可能允许在CT衰减和FDG摄取之间得出更精确的关系。

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