...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cell metabolism >Epigenome-Wide Association of Liver Methylation Patterns and Complex Metabolic Traits in Mice
【24h】

Epigenome-Wide Association of Liver Methylation Patterns and Complex Metabolic Traits in Mice

机译：小鼠肝脏甲基化模式与复杂代谢性状的表观基因组关联

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Heritable epigenetic factors can contribute to complex disease etiology. Here we examine the contribution of DNA methylation to complex traits that are precursors to heart disease, diabetes, and osteoporosis. We profiled DNA methylation in the liver using bisulfite sequencing in 90 mouse inbred strains, genome-wide expression levels, proteomics, metabolomics, and 68 clinical traits and performed epigenome-wide association studies (EWAS). We found associations with numerous clinical traits including bone density, insulin resistance, expression, and protein and metabolite levels. A large proportion of associations were unique to EWAS and were not identified using GWAS. Methylation levels were regulated by genetics largely in cis, but we also found evidence of trans regulation, and we demonstrate that genetic variation in the methionine synthase reductase gene Mtrr affects methylation of hundreds of CpGs throughout the genome. Our results indicate that natural variation in methylation levels contributes to the etiology of complex clinical traits.
机译：可遗传的表观遗传因素可导致复杂的疾病病因。在这里，我们研究了DNA甲基化对心脏病，糖尿病和骨质疏松症前兆等复杂性状的贡献。我们在90个小鼠自交系中使用亚硫酸氢盐测序，了全基因组表达水平，蛋白质组学，代谢组学和68种临床特征，对肝脏中的DNA甲基化进行了分析，并进行了表观基因组范围的关联研究（EWAS）。我们发现与许多临床特征有关，包括骨密度，胰岛素抵抗，表达，蛋白质和代谢物水平。很大一部分关联是EWAS特有的，无法使用GWAS识别。甲基化水平主要由顺式遗传来调节，但是我们也发现了反式调节的证据，并且我们证明了蛋氨酸合酶还原酶基因Mtrr的遗传变异会影响整个基因组中数百个CpG的甲基化。我们的结果表明，甲基化水平的自然变化有助于复杂临床特征的病因学。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号