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Modifying the function of DNA repair nanomachines for therapeutic benefit

机译:修改DNA修复纳米机的功能以获得治疗益处

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This article,which is based on a presentation at the First Annual Meeting of the American Academy of Nanomedicine,is divided into three parts.First,we describe naturally occurring DNA repair nanomachines,using as an example the nanomachine that executes the nonhomologous end-joining (NHEJ) reaction for DNA double-strand break (DSB) repair.Second,we discuss therapeutic benefits that may be derived from the ability to modify the behavior of naturally occurring nanomachines, using as an example the concept of delaying DSB repair in rapidly dividing cancer cells to increase their natural sensitivity to radiation therapy.Third,we discuss similarities in the overall size,shape, and design of different nanomachines that manipulate DNA and RNA,and the possibility of developing nanomachines with new specificities not found in nature.
机译:本文基于在美国纳米医学科学院第一届年会上的演讲,分为三个部分。首先,我们描述天然存在的DNA修复纳米机器,以执行非同源末端连接的纳米机器为例。 (NHEJ)反应进行DNA双链断裂(DSB)修复。其次,我们讨论了可通过改变天然存在的纳米机器行为的能力而获得的治疗益处,以延迟DSB修复快速分裂的概念为例第三,我们讨论了操纵DNA和RNA的不同纳米机器的整体大小,形状和设计的相似性,以及开发具有自然界中未发现的新特异性的纳米机器的可能性。

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