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首页> 外文期刊>Laboratory Animal Science >Stress-related hormonal and metabolic responses to restraint, with and without butorphanol administration, in pre-conditioned goats
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Stress-related hormonal and metabolic responses to restraint, with and without butorphanol administration, in pre-conditioned goats

机译：预处理山羊在有或没有丁烷醇的情况下与应激相关的激素和代谢反应对束缚的反应

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Twelve goats were pre-conditioned to handling, restraint, instrumentation, clippers and the experimental room. On the day of the trial, goats were confined in a stanchion, with or without administration of butorphanol (0.1 mg/kg of body weight, i.v.), in a cross-over design experiment. Heart and respiratory rates were measured at baseline (0), 15, 30, 45, 60, 75, 90, 105 and 120 min. Rectal temperature was measured and blood samples were collected at baseline and 30, 60, 90 and 120 min. Epinephrine, norepinephrine, cortisol, glucose and free fatty acid concentrations were measured. At all times, glucose concentration was significantly lower when butorphanol, compared with saline, was administered. Baseline concentration of free fatty acids was significantly higher than that at all other times for either treatment. Differences for treatment or time were not significant for epinephrine, norepinephrine or cortisol values. There was a significant treatment and time interaction for respiratory rate, heart rate and rectal temperature. Respiratory rate was significantly higher at 60 min after butorphanol treatment, compared with saline treatment. Heart rate was significantly higher at 75 min than at baseline, and rectal temperature was significantly higher at 30 than 120 min. It is suggested that the analgesic efficacy of butorphanol can be more rationally evaluated in goats experiencing pain because the response in goats not experiencing pain is now known.
机译：对十二只山羊进行了预处理，以适应处理，约束，仪器，剪刀和实验室的要求。在试验的当天，在交叉设计实验中，山羊在有或没有施用布托啡诺（0.1 mg / kg体重，静脉注射）的情况下被限制在立柱中。在基线（0），15、30、45、60、75、90、105和120分钟时测量心脏和呼吸频率。在基线和30、60、90和120分钟时测量直肠温度并收集血样。测定肾上腺素，去甲肾上腺素，皮质醇，葡萄糖和游离脂肪酸的浓度。在任何时候，与盐水相比，丁苯啡诺的葡萄糖浓度均显着降低。两种治疗方法中游离脂肪酸的基线浓度均显着高于所有其他时间。肾上腺素，去甲肾上腺素或皮质醇值的治疗或时间差异均无统计学意义。呼吸频率，心率和直肠温度存在显着的治疗和时间交互作用。与生理盐水治疗相比，丁苯啡诺治疗后60分钟的呼吸频率明显更高。 75分钟时的心率显着高于基线，而30分钟时的直肠温度显着高于120分钟。建议在患有疼痛的山羊中可以更合理地评估布托啡诺的镇痛效果，因为现在已知在没有疼痛的山羊中的反应。

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