• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Laboratory Animal Science >Appearance of morphologically abnormal Sertoli cells in infertile PD male rats during postnatal development.
【24h】

Appearance of morphologically abnormal Sertoli cells in infertile PD male rats during postnatal development.

机译：出生后不育PD雄性大鼠形态学异常的支持细胞的外观。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Previous studies using 12-week-old polydactylic (pd/pd) male rats have indicated a high incidence of morphologically abnormal Sertoli cells. Because sterility in these males was attributable to abnormal spermatogenesis, it was suggested that abnormal Sertoli cells were related to abnormal spermatogenesis. In the present study, testes of 7- and 21-day-old male pd/pd rats were examined ultrastructurally; pd/+ males served as controls. At 7 days of age, light and dark type Sertoli cells were found inpd/pd males. However, no anatomic abnormality existed in those cells. Cytoplasmic organelles were underdeveloped. The only difference between the light and dark cells was the high electron density in the nucleus and cytoplasm of the dark cells. These features were similar in pd/pd and pd/+ males. At 21 days, dark Sertoli cells had disappeared, and light Sertoli cells and abnormal Sertoli cells were observed in pd/pd males. Light Sertoli cells had well-developed cytoplasmic organelles. Abnormal Sertoli cells had a dark appearance, irregularly shaped nuclei and a large quantity of lipid droplets in the cytoplasm. These results suggested the presence of functional disorders in lipid metabolism. The light and abnormal Sertoli cells also were found in pd/+males; however, the incidence of abnormal Sertoli cells was significantly higher in pd/pd males (11.3%) than in pd/+ males (4.9%). Thus, these results indicate that, in pd/pd male rats, a number of abnormal Sertoli cells appear by 21 days of age.
机译：先前使用12周大的多指（pd / pd）雄性大鼠进行的研究表明，形态异常的Sertoli细胞的发生率很高。由于这些雄性动物的不育归因于异常的精子发生，因此提示异常的支持细胞与异常的精子发生有关。在本研究中，对7日龄和21日龄雄性pd / pd大鼠的睾丸进行超微结构检查。 pd / +雄性作为对照。在7天龄时，发现在pd / pd雄性中有亮和暗型Sertoli细胞。但是，这些细胞中不存在解剖异常。细胞质细胞器不发达。亮细胞和暗细胞之间的唯一区别是暗细胞的细胞核和细胞质中的电子密度高。这些特征在pd / pd和pd / +男性中相似。在21天时，在pd / pd雄性中观察到深色的Sertoli细胞消失，并观察到浅色Sertoli细胞和异常的Sertoli细胞。轻型支持细胞具有发达的细胞质细胞器。异常的支持细胞呈深色，细胞核形状不规则，胞质中有大量脂滴。这些结果表明脂质代谢中存在功能障碍。在pd / +雄性中也发现了轻度和异常的Sertoli细胞。但是，pd / pd雄性（11.3％）的异常Sertoli细胞发生率明显高于pd / +雄性（4.9％）。因此，这些结果表明，在pd / pd雄性大鼠中，到21日龄时出现许多异常的支持细胞。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号