• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Laboratory Animal Science >BACTERIAL LIPOPOLYSACCHARIDES INDUCE PERIPHERAL NERVE DISTURBANCES IN RATS THAT MIMIC HUMAN IMMUNE-MEDIATED POLYNEUROPATHIES
【24h】

BACTERIAL LIPOPOLYSACCHARIDES INDUCE PERIPHERAL NERVE DISTURBANCES IN RATS THAT MIMIC HUMAN IMMUNE-MEDIATED POLYNEUROPATHIES

机译：细菌脂多糖对模拟人免疫介导的多发性神经病大鼠的周围神经干扰

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A single injection of Escherichia coli lipopolysaccharide (LPS; i.v and i.p.) reliably induced peripheral nerve disturbances in male Australian albino Wistar (AaW) rats, Signs developed 6 to 24 h after LPS inoculation and persisted only transiently Most AaW rats had variable degrees of bilateral hind limb impairment, and rarely had forelimb, tail, or central impairment. Signs included gait abnormalities, proprioceptive loss, and to a lesser extent hind limb weakness and sensory deficits, Signs were more severe in male than female AaW rats and were induced in a number of genetically related rat strains (e.g., AaW and outbred Wistar and inbred Lewis rats, but not Sprague Dawley or inbred Fischer 344 rats), Development and severity of these signs were found not to be related to animal body weight, but were dependent on LPS dose, Signs were not associated with LPS-induced alterations in pain perception, or occurrence of spontaneous pain, as indexed by tail-flick and hot-plate tests, Taken together, these data indicate that LPS induced transient peripheral nerve disturbances in rats, the severity of which was influenced by genetic, sex-related, and dose-related factors.
机译：单次注射大肠埃希氏菌脂多糖（LPS; iv和ip）可靠地诱导了雄性澳大利亚白化Wistar（AaW）大鼠的周围神经障碍，LPS接种后6至24小时出现了体征，并且仅持续存在，大多数AaW大鼠的双侧程度都不同后肢损伤，很少有前肢，尾巴或中枢损伤。体征包括步态异常，本体感受力丧失以及后肢无力和感觉缺陷程度较轻。雄性体征比雌性AaW大鼠更为严重，并在许多与遗传相关的大鼠品系（例如AaW和近交Wistar和近交系）中诱发Lewis大鼠，但不是Sprague Dawley或近亲Fischer 344大鼠），这些体征的发展和严重程度与动物体重无关，但与LPS剂量有关，体征与LPS引起的疼痛知觉改变无关总的来说，这些数据表明LPS会诱发大鼠短暂性周围神经障碍，其严重程度受遗传，性别相关和剂量的影响相关因素。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号