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首页> 外文期刊>Laboratory Animal Science >EVALUATION OF A VAGINAL MOISTURIZER IN BABOONS WITH DECREASING OVARIAN FUNCTION
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EVALUATION OF A VAGINAL MOISTURIZER IN BABOONS WITH DECREASING OVARIAN FUNCTION

机译：卵巢功能下降的狒狒阴道保湿剂的评价。

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Decrease of estrogen concentrations in postmenopausal women leads to many urogenital problems including vaginal dryness, atrophy, stenosis, itching, and irritation, along with sexual dysfunction. Systemic estrogen replacement is effective in many women but may not be effective in others because estrogen therapy may be contraindicated for medical reasons. The reproductive tract in nonhuman female primates has been used successfully as a model for a variety of research including, but not limited to, anatomy and physiology, reproduction, cancer, infectious disease, and menopause. The baboon is especially valuable because of the similarity of its menstrual cycle to women's, prior research with this animal, and its adaptability to captivity. A nonhormonal, nonsystemic, bio-adhesive vaginal moisturizer was evaluated in baboons as a possible alternative to hormonal therapy for vaginal symptoms due to a decrease in estrogen concentrations. Eight baboons with decreasing ovarian function were used in a two part study to evaluate vaginal health with pliability, elasticity, mucosal secretion, pH, and histologic features as criteria. The first study involved a single intravaginally administered dose of test product, with evaluation at 20 min and 24 h later. The second study consisted of five doses given at 24-h intervals, with daily evaluations for 9 consecutive days. There was marked improvement in vaginal pliability, elasticity, and secretions, with decreased pH and thickness of the vaginal epithelium. These effects appeared 1 or 2 days after drug administration, reached the maximum on day 4, and mostly decreased by day 8. However, increased secretions, vaginal elasticity, and vacuolization of the epithelium in biopsy specimens persisted to the last day of observation. The study results indicate the efficacy of the test product and the value of the baboon as a model to study decreasing ovarian function and vaginal health.
机译：绝经后妇女体内雌激素浓度降低会导致许多泌尿生殖系统疾病，包括阴道干燥，萎缩，狭窄，瘙痒和刺激，以及性功能障碍。全身性雌激素替代在许多女性中有效，但在其他女性中可能无效，因为出于医学原因，雌激素治疗可能被禁忌。非人类女性灵长类动物的生殖道已成功用作各种研究的模型，包括但不限于解剖学和生理学，生殖，癌症，传染病和更年期。狒狒之所以特别有价值，是因为它的月经周期与女性相似，先前对该动物的研究以及它对人工饲养的适应性。由于雌激素浓度降低，在狒狒中评估了一种非激素，非全身性，生物粘附性阴道保湿剂，作为激素疗法对阴道症状的一种可能替代方法。在一项分为两部分的研究中，使用了八只狒狒的卵巢功能下降，以柔韧性，弹性，粘膜分泌物，pH和组织学特征为标准，评估了阴道的健康状况。第一项研究涉及单一剂量的阴道内给药测试产品，并在20分钟和24小时后进行评估。第二项研究包括每24小时间隔服用五剂，连续9天每天进行评估。阴道柔韧性，弹性和分泌物显着改善，阴道上皮的pH值和厚度降低。这些作用在给药后1或2天出现，在第4天达到最大，并在第8天大多减弱。但是，活检样品的分泌增加，阴道弹性和上皮液化持续到观察的最后一天。研究结果表明测试产品的功效和狒狒作为研究卵巢功能下降和阴道健康的模型的价值。

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