RAPID CARCINOGENICITY TESTING SYSTEM WITH TRANSGENIC MICE HARBORING HUMAN PROTOTYPE C-HRAS GENE

Yamamoto S; Hayashi Y; Mitsumori K; Nomura T

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RAPID CARCINOGENICITY TESTING SYSTEM WITH TRANSGENIC MICE HARBORING HUMAN PROTOTYPE C-HRAS GENE

机译：携带人类原型C-HRAS基因的转基因小鼠快速致癌性检测系统

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Rapid carcinogenicity tests were done with transgenic (Tg) mice human prototype c-HRAS gene, namely BALB/cByJxC57BL/6JF1-TgN(HRAS)2 or CB6F1-HRAS2 mice. The studies were conducted as the first step in the evaluation of the CB6F1-HRAS2 mouse as a model for the rapid carcinogenicity testing system. Results of short-term tests of various genotoxic carcinogens indicated that CB6F1-HRAS2 mice are more susceptible to these carcinogens than control non-Tg mice. According to the first-step evaluation studies, more rapid onset and a higher incidence of more malignant tumors can be expected with a higher probability after treatment with various genotoxic carcinogens in the CB6F1-HRAS2 mice that in control non-Tg mice. The CB6F1-HRAS2 mouse seems to be a promising candidate as an animal model for the development of a rapid carcinogenicity testing system.

机译：使用转基因（Tg）小鼠人类原型c-HRAS基因，即BALB / cByJxC57BL / 6JF1-TgN（HRAS）2或CB6F1-HRAS2小鼠，进行了快速致癌性测试。这项研究是在评估CB6F1-HRAS2小鼠（作为快速致癌性测试系统的模型）的第一步。各种遗传毒性致癌物的短期测试结果表明，与对照非Tg小鼠相比，CB6F1-HRAS2小鼠对这些致癌物更易感。根据第一步评估研究，在使用各种遗传毒性致癌物治疗CB6F1-HRAS2小鼠后，可以比预期的非Tg小鼠更快，更迅速地发生恶性肿瘤。作为开发快速致癌性测试系统的动物模型，CB6F1-HRAS2小鼠似乎是很有希望的候选者。

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《Laboratory Animal Science》 |1997年第2期|共6页
作者
Yamamoto S; Hayashi Y; Mitsumori K; Nomura T;
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正文语种 eng
中图分类动物学实验（实验动物学）、动物学技术;
关键词
Lung tumors; Protooncogene activation; Rodent carcinogenicity; Liver; carcinogenesis; Ras oncogenes; Susceptibility; Model.; Hepatocarcinogenesis; Mutations; Chemicals;

机译：肺肿瘤;原癌基因激活;啮齿类动物致癌性;肝脏;致癌作用;Ras癌基因;易感性;模型;肝癌致突变作用;突变;化学物质;

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专利

1. RAPID CARCINOGENICITY TESTING SYSTEM WITH TRANSGENIC MICE HARBORING HUMAN PROTOTYPE C-HRAS GENE [J] . Yamamoto S, Hayashi Y, Mitsumori K, Laboratory Animal Science . 1997,第2期

机译：携带人类原型C-HRAS基因的转基因小鼠快速致癌性检测系统
2. Effect of Mouse Intestinal Bacteia on Incidence of Colorectal Tumors Induced by 1,2-dimethylhydrazine Injection in Gnotobiotic Transgenic Mice Harboring Human Prototype c-Ha-ras Genes [J] . Seiko Narushima, Kikuki Itoh, Tomotari Mitsuoka Experimental Animals . 1998,第2期

机译：小鼠肠道细菌对携带人原型c-Ha-ras基因的转基因小鼠转基因小鼠经1,2-二甲基肼注射诱导大肠肿瘤发生的影响
3. Susceptibility of transgenic mice carrying human prototype c-Ha-ras gene in a short-term carcinogenicity study of vinyl carbamate and ras gene analyses of the induced tumors. [J] . Mitsumori K, Wakana S, Yamamoto S, Molecular Carcinogenesis . 1997,第3期

机译：载有人类原型c-Ha-ras基因的转基因小鼠的易感性，氨基甲酸乙烯基酯的短期致癌性研究和ras基因分析引起的肿瘤。
4. The Hormone Response Element (HRE) of the Human ApoCIII Enhancer Is Essential for the Intestinal Expression of the Human Apoa-I Gene in Transgenic Mice [C] . Horng Yuan Kan, Spiros Georgopoulos, Eleni Zanni, NATO Advanced Study Institute on Vascular Endothelium : Mechanisms of Cell Signaling . 1999

机译：人Apociii Enhancer的激素应答元件（HRE）对于转基因小鼠中人Apoa-I基因的肠道表达至关重要
5. Rapid prototyping and evaluation of dialogue systems for virtual humans [D] . Gandhe, Sudeep 2014

机译：虚拟人对话系统的快速原型制作和评估
6. Validation of transgenic mice carrying the human prototype c-Ha-ras gene as a bioassay model for rapid carcinogenicity testing. [O] . S Yamamoto, K Urano, H Koizumi, 1998

机译：验证携带人类原型c-Ha-ras基因的转基因小鼠作为快速致癌性测试的生物测定模型。
7. Validation of transgenic mice carrying the human prototype c-Ha-ras gene as a bioassay model for rapid carcinogenicity testing. [O] . Yamamoto, S, Urano, K, Koizumi, H, 1998

机译：验证携带人类原型c-Ha-ras基因的转基因小鼠作为快速致癌性测试的生物测定模型。

RAPID CARCINOGENICITY TESTING SYSTEM WITH TRANSGENIC MICE HARBORING HUMAN PROTOTYPE C-HRAS GENE

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