• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Laboratory Animal Science >Evaluation and characterization of congenital hypothyroidism in rdw dwarf rats
【24h】

Evaluation and characterization of congenital hypothyroidism in rdw dwarf rats

机译：rdw矮性大鼠先天性甲状腺功能减退的评估和特征

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The rdw rat is a new strain of dwarf mutant that has decreased blood thyroxine (T_4) and growth hormone (GH) concentrations and testicular enlargement during development and aging. To confirm whether this strain can be used as a new hypothyroid model, the experiments reported here were carried out, using adult rdw rats, rdw rats treated with thyroxine, and clinically normal (N) Wistar-Imamichi rats. Clinical parameters of deficient thyroid function in rdw rats were chosen for evaluation and characterization. Body weight, hemoglobin (Hb) concentration, hematocrit (Hct), glucose (GLU), and systolic blood pressure were significantly lower, and serum values for aspartate transaminase (AST), total cholesterol (TC), total protein (TP), and blood urea nitrogen (BUN) were higher in rdw than in N rats. Serum concentrations of total T_4 and free triiodothyronine (FT_3) were significantly lower, and serum thyroid-stimulation hormone (TSH) concentration was markedly higher in rdw than in N rats. Serum GH concentration was significantly lower in rdw than in N rats. Results of histologic examination indicated that the thyroid gland of rdw rats was markedly atrophied, compared with that of N rats. Results of clinical examination of organs and hematologic and biochemical values in rdw rats corresponded to those of the hypothyroid state in humans. Most organ weights (heart, kidney, spleen, and adrenal gland), hematologic and biochemical values (Hb, Hct TC, TP, BUN), blood pressure, and serum hormone (TSH and GH) values underwent substantial restoration (partial or complete) toward normal in response to replacement therapy. In conclusion, the rdw rat is a useful model of congenital hypothyroidism.
机译：rdw大鼠是新的矮人突变株，在发育和衰老过程中其血液甲状腺素（T_4）和生长激素（GH）浓度降低，睾丸增大。为了确认该菌株是否可以用作新的甲状腺功能减退模型，使用成年rdw大鼠，甲状腺素治疗的rdw大鼠和临床正常（N）Wistar-Imamichi大鼠进行了此处报道的实验。选择rdw大鼠甲状腺功能不足的临床参数进行评估和表征。体重，血红蛋白（Hb）浓度，血细胞比容（Hct），葡萄糖（GLU）和收缩压均显着降低，并且天冬氨酸转氨酶（AST），总胆固醇（TC），总蛋白（TP）和rdw的血尿素氮（BUN）高于N大鼠。血清中总T_4和游离三碘甲状腺素（FT_3）的浓度显着降低，rdw的血清甲状腺刺激激素（TSH）浓度显着高于N大鼠。 rdw的血清GH浓度显着低于N大鼠。组织学检查结果表明，与N组相比，rdw大鼠的甲状腺明显萎缩。 rdw大鼠的器官临床检查结果和血液生化值与人类甲状腺功能减退的结果相符。大多数器官重量（心脏，肾脏，脾脏和肾上腺），血液和生化值（Hb，Hct TC，TP，BUN），血压和血清激素（TSH和GH）值均得到了实质性恢复（部分或完全）对替代疗法反应正常。总之，rdw大鼠是先天性甲状腺功能减退的有用模型。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号