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首页> 外文期刊>Cell biology international. >Electrically induced gel-to-gel phase-transition in neurons.
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Electrically induced gel-to-gel phase-transition in neurons.

机译：神经元中电诱导的凝胶到凝胶的相变。

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At the end of transcardial perfusions with ice-cold physiological saline for 30 min or with isoosmotic potassium chloride for 5 min, but immediately before perfusion fixation, condenser-discharge electric shocks were administered to rats through surface electrodes pressed onto the temporal muscles of the scalped skull. As a result, striking ultrastructural compaction came about in numerous neurons thinly scattered in certain brain areas. Its features displayed a high degree of similarity to those previously observed following the in vivo administration of the same kind of electric shocks. This surprising independence from the actual state of metabolism questions whether the ultrastructural compaction, induced either in vivo or post mortem, is the result of any cascade of enzyme-mediated processes. On the other hand, a physical mechanism, phase transition propagated by non-covalent free energy stored in a cytoplasmic gel structure, which was proposed recently to explain a mechanically induced similar ultrastructural compaction, appears to apply also to the present case.
机译：在用冰冷的生理盐水进行30分钟或等渗氯化钾进行5次心动过流灌注结束时，但在灌注固定之前，立即通过表面电极将电容器放电电击施加到大鼠，电极压在剥皮的颞肌上头骨。结果，在某些大脑区域稀疏散布的众多神经元中发生了惊人的超结构压实。其特征与体内给予相同类型的电击后先前观察到的特征具有高度相似性。这种与实际代谢状态的出乎意料的独立性质疑了体内或验尸诱导的超微结构压缩是酶介导过程的任何级联的结果。另一方面，最近提出的用于解释机械诱导的类似超微结构压缩的物理机制，由存储在细胞质凝胶结构中的非共价自由能传播的相变似乎也适用于本案。

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