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首页> 外文期刊>Laser Physics: An International Journal devoted to Theoretical and Experimental Laser Research and Application >Differentiation of oral precancerous stages with optical coherence tomography based on the evaluation of optical scattering properties of oral mucosae
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Differentiation of oral precancerous stages with optical coherence tomography based on the evaluation of optical scattering properties of oral mucosae

机译：基于口腔黏膜光学散射特性的光学相干断层扫描法对口腔癌前期的区分

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摘要

Optical coherence tomography (OCT) has been demonstrated to be a powerful tool for noninvasive, real-time oral cancer diagnosis. However, in previous reports, OCT has still been found to be difficult to use in the diagnosis of oral precancerous stages, including mild dysplasia and moderate dysplasia. In clinical applications, early diagnosis and treatment of oral cancer can greatly improve the survival rate. Therefore, in this study, we propose a new approach to differentiate the oral precancerous stages based on the evaluation of the optical scattering properties of the epithelial layer, which is where the dysplastic cells start to develop in the precancerous stages. Instead of using exponential decay fitting to evaluate the scattering properties of mucosal tissues based on the Beer-Lambert law, linear fitting of the OCT depth intensity is used to evaluate the scattering properties of normal and dysplastic cells. From the statistical results of the linear fitting, the slope, a, can be an effective indicator to discriminate healthy mucosa and moderate dysplasia when an a value equal to zero is the threshold value, and the intercept, b, can be used to differentiate healthy and dysplastic mucosae, as well as mild and moderate dysplasia, when b values of 0.15 and 0.18 are used as the threshold values, respectively. Furthermore, this approach is also applied to the determination of the safe margin between normal and abnormal mucosae, making it possible to provide real-time, in vivo inspection during oral maxillofacial surgery.
机译：光学相干断层扫描（OCT）已被证明是无创，实时口腔癌诊断的强大工具。但是，在以前的报道中，仍发现难以将OCT用于诊断口腔癌前期，包括轻度不典型增生和中度不典型增生。在临床应用中，早期诊断和治疗口腔癌可以大大提高生存率。因此，在这项研究中，我们基于对上皮层的光散射特性的评估，提出了一种区分口腔癌前期的新方法，这是增生细胞在癌前期开始发展的地方。代替基于比尔-朗伯定律使用指数衰减拟合来评估粘膜组织的散射特性，而是使用OCT深度强度的线性拟合来评估正常细胞和增生细胞的散射特性。从线性拟合的统计结果来看，当a值等于零时，斜率a可以作为区分健康黏膜和中度发育不良的有效指标，截距b可以用来区分健康当b值分别为0.15和0.18时，粘膜和增生异常，以及轻度和中度不典型增生。此外，该方法还适用于确定正常和异常粘膜之间的安全裕度，从而有可能在口腔颌面外科手术期间提供实时的体内检查。

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