• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cell and Tissue Research >Hereditary barrier-related diseases involving the tight junction: lessons from skin and intestine
【24h】

Hereditary barrier-related diseases involving the tight junction: lessons from skin and intestine

机译：涉及紧密连接的遗传性障碍相关疾病：皮肤和肠道的经验教训

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The tight junction (TJ) regulates paracellular barrier properties. TJs are composed of transmembrane proteins, i.e., claudins, occludin, tricellulin and junctional adhesion molecules as well as TJ plaque proteins. Their relative abundance and composition determines epithelial tightness. TJs undergo rapid regulation by various signalling pathways, either directly addressing TJ transmembrane proteins or via plaque proteins and the cytoskeleton. In the skin, TJs exert predominantly barrier functions, while in the intestine they also mediate paracellular ion and water transport. In diseases, TJs can either be primarily affected (hereditary TJ defects) or changes can result from secondary regulatory inputs as, e.g., in inflammatory diseases (secondary TJ defects). Secondary TJ defects can maintain disease activity, e.g., by enhanced antigen leak. This review discusses TJ composition, function and regulation as well as primary and secondary tight junction defects in a comparative manner in skin and intestine in order to elucidate similarities and differences.
机译：紧密连接（TJ）调节细胞旁屏障特性。 TJ由跨膜蛋白即claudins，occludin，tricellulin和连接黏附分子以及TJ噬斑蛋白组成。它们的相对丰度和组成决定了上皮的紧密度。 TJ通过各种信号传导途径进行快速调节，可以直接处理TJ跨膜蛋白，也可以通过噬菌斑蛋白和细胞骨架。 TJ在皮肤中主要发挥屏障功能，而在肠中它们也介导细胞旁离子和水的运输。在疾病中，TJ可能受到主要影响（遗传性TJ缺陷），或者继发性调节输入可能导致变化，例如在炎症性疾病中（继发性TJ缺陷）。继发性TJ缺陷可以例如通过增强抗原泄漏来维持疾病活性。这篇综述以比较的方式讨论了皮肤和肠道中的TJ组成，功能和调节以及原发性和继发性紧密连接缺陷，以阐明相似性和差异性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号