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首页> 外文期刊>Cell biology international. >An in vitro model to evaluate cell adhesion to metals used in implantation shows significant differences between palladium and gold or platinum.
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An in vitro model to evaluate cell adhesion to metals used in implantation shows significant differences between palladium and gold or platinum.

机译：用于评估细胞对植入金属的粘附力的体外模型显示，钯与金或铂之间存在显着差异。

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摘要

Adhesion of tissue cells to metallic implants is a major factor that is important for proper tissue integration. Adhesion of Swiss mouse 3T3 fibroblasts to gold, platinum and palladium surfaces was investigated. Immunofluorescence staining for the integrin subunits alphav and beta1 and the focal contact protein vinculin revealed that cells growing on gold and platinum expressed many focal contacts. In contrast, cells on palladium surfaces had reduced numbers of focal contacts shown by vinculin staining and failed to demonstrate expression of alphav and beta1 in focal contacts. Spread cell area was also significantly reduced on palladium than on other surfaces suggesting that cells on palladium were more weakly attached. This may be due to either a different molecular composition of focal contacts in cells grown on palladium surfaces or unusual microstructural properties of the palladium surface. This model is useful to evaluate adhesion of cells to different metal surfaces.
机译：组织细胞对金属植入物的粘附是对适当的组织整合很重要的主要因素。研究了瑞士小鼠3T3成纤维细胞对金，铂和钯表面的粘附力。整联蛋白亚基alphav和beta1的免疫荧光染色以及焦点接触蛋白vinculin染色显示，在金和铂上生长的细胞表达许多焦点接触。相反，钯表面上的细胞通过纽蛋白染色显示的焦点接触数量减少，并且未能证明焦点接触中αv和beta1的表达。与其他表面相比，钯上的散布细胞面积也显着减少，这表明钯上的细胞附着力更弱。这可能是由于钯表面上生长的细胞中焦点接触的分子组成不同或钯表面具有异常的微观结构特性所致。该模型对于评估细胞对不同金属表面的粘附力很有用。

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