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首页> 外文期刊>Cell and Tissue Research >Crohn's disease: ultrastructure of interstitial cells in colonic myenteric plexus.
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Crohn's disease: ultrastructure of interstitial cells in colonic myenteric plexus.

机译：克罗恩氏病：结肠肌层神经丛中的间质细胞超微结构。

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摘要

The role of the interstitial cells of Cajal (ICC) in chronic inflammatory bowel disease, i.e., ulcerative colitis (UC) and Crohn's disease (CD), remains unclear. Ultrastructural alterations in ICC in the colonic myenteric plexus (ICC-MP) have been reported previously in UC, but descriptions of ICC-MP and other interstitial cells in the myenteric region of the colon are lacking for CD. In the present study, we characterized the ultrastructure of interstitial cells, nerves, and glial cells in the myenteric region in Crohn's colitis (CC). In comparison with controls, varicosities of the myenteric bundles were dilated and appeared to be empty. Lipid droplets and lipofuscin-bodies were prominent in glial cells and neurons. ICC-MP were scanty but, as in controls, had caveolae, prominent intermediate filaments, cytoplasmic dense bodies, and membrane-associated dense bands with a patchy basal lamina. ICC-MP were similar in the various colonic regions. ICC-MP in CC showed no signs of degeneration or cytological changes. As in controls, fibroblast-like cells had abundant coated vesicles but lacked prominent intermediate filaments and caveolae. Macrophages also appeared as in controls. In comparison with ICC-MP in UC, the cytology of ICC-MP in CC were thus undisturbed. The ultrastructural differences between UC and CC might reflect pathophysiological differences of importance for understanding pathogenetic differences between CD and UC.
机译：在慢性炎症性肠病，即溃疡性结肠炎（UC）和克罗恩氏病（CD）中，Cajal的间质细胞（ICC）的作用尚不清楚。先前已在UC中报道了结肠肌层神经丛（ICC-MP）中ICC的超微结构改变，但对CD缺乏对ICC-MP和结肠间质区域其他间质细胞的描述。在本研究中，我们表征了克罗恩结肠炎（CC）的肌层区域间质细胞，神经和神经胶质细胞的超微结构。与对照相比，肠肌束的静脉曲张扩张并且显得是空的。脂滴和脂褐素体在神经胶质细胞和神经元中突出。 ICC-MP很少，但与对照组一样，有海绵状小孔，突出的中间细丝，胞质致密体和膜相关性致密带，基底膜片状。在各个结肠区域中，ICC-MP相似。 CC中的ICC-MP未显示变性或细胞学改变的迹象。与对照组一样，成纤维细胞样细胞具有丰富的包被囊泡，但缺乏明显的中间丝和小窝。巨噬细胞也出现在对照中。与UC中的ICC-MP相比，CC中的ICC-MP的细胞学不受干扰。 UC和CC之间的超微结构差异可能反映了病理生理差异，对于理解CD和UC之间的致病差异具有重要意义。

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