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Jumonji family histone demethylases in neural development

机译:Jumonji家族组蛋白脱甲基酶在神经发育中的作用

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摘要

Central nervous system (CNS) development is driven by coordinated actions of developmental signals and chromatin regulators that precisely regulate gene expression patterns. Histone methylation is a regulatory mechanism that controls transcriptional programs. In the last 10 years, several histone demethylases (HDM) have been identified as important players in neural development, and their implication in cell fate decisions is beginning to be recognized. Identification of the physiological roles of these enzymes and their molecular mechanisms of action will be necessary for completely understanding the process that ultimately generates different neural cells in the CNS. In this review, we provide an overview of the Jumonji family of HDMs involved in neurodevelopment, and we discuss their roles during neural fate establishment and neuronal differentiation.
机译:中枢神经系统(CNS)的发展由发育信号和精确调节基因表达模式的染色质调节剂的协调作用所驱动。组蛋白甲基化是控制转录程序的调节机制。在过去的十年中,已经确定了几种组蛋白脱甲基酶(HDM)是神经发育中的重要角色,并且它们在细胞命运决定中的意义也开始得到认可。这些酶的生理作用及其分子作用机理的鉴定对于完全理解最终在CNS中产生不同神经细胞的过程是必不可少的。在这篇综述中,我们概述了参与神经发育的HDM Jumonji系列,并讨论了它们在神经命运建立和神经元分化过程中的作用。

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