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TYROSINE METABOLISM IN USERS OF ORAL CONTRACEPTIVES

机译：口服避孕药中的酪氨酸代谢

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Brain noradrenaline takes part in the regulation of several brain functions. The formation of brain noradrenaline depends on brain tyrosine (Tyr) levels, which associates with the ratio in plasma of Tyr to other large, neutral amino acids (LNAA): Tyr metabolism has been studied in users of the new generation combined oral contraceptives (OC) and comparable controls at the follicular, mid-cycle, and luteal phases of the menstrual cycle. OC users showed significantly increased plasma Tyr transaminase activity, and significantly decreased plasma Tyr and Tyr/LNAA levels at mid-cycle and luteal phase, whereas plasma total 3-methoxy-4-hydroxyphenylglycol (MHPG) was not affected. Following an oral protein load, the area under the curve in plasma of Tyr and Tyr/LNAA in OC users at the luteal phase were 43 % and 29 %, respectively, of control levels. The results suggest that the decreased Tyr availability to the brain in OC users may result in a substrate-limited reduction of brain noradrenaline formation, which, secondarily, may contribute to disturbances of mood, coping mechanisms, and appetite in susceptible subjects. [References: 40]
机译：脑去甲肾上腺素参与多种脑功能的调节。脑中去甲肾上腺素的形成取决于脑酪氨酸（Tyr）水平，该水平与血浆Tyr与其他大型中性氨基酸（LNAA）的比例有关：新一代联合口服避孕药（OC）的使用者已经研究了Tyr代谢）以及在月经周期的卵泡期，中期和黄体期的类似对照。 OC使用者显示血浆Tyr转氨酶活性显着增加，并且在周期中期和黄体期显着降低血浆Tyr和Tyr / LNAA水平，而血浆总3-甲氧基-4-羟苯基乙二醇（MHPG）不受影响。口服蛋白质后，黄体期OC使用者的血浆Tyr和Tyr / LNAA曲线下面积分别为对照水平的43％和29％。结果表明，OC使用者对大脑的Tyr利用率降低可能会导致底物有限的大脑去甲肾上腺素形成减少，其次，这可能会导致易感受试者的情绪，应对机制和食欲不佳。 [参考：40]

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