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首页> 外文期刊>Life sciences >Hepatic glutathione determination after ethanol administration in rat: evidence of the first-pass metabolism of ethanol.
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Hepatic glutathione determination after ethanol administration in rat: evidence of the first-pass metabolism of ethanol.

机译：大鼠服用乙醇后测定肝谷胱甘肽：乙醇首过代谢的证据。

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摘要

As a fraction of ingested ethanol is metabolized by gastric mucosa, different amounts of alcohol should reach the liver when the same dose is administered by oral or intravenous route. Therefore, we investigated the time-course of hepatic reduced glutathione (GSH) concentrations after intra-peritoneal or intra-gastric load of the same amount of ethanol in the rat. The test was also performed in fasted and Cimetidine-treated rats. The oral ethanol administration was followed by a less pronounced decrease and by a quicker recovery of hepatic content of GSH than after intraperitoneal route. In the fasted rat, basal hepatic GSH significantly decreased; after alcohol administration the decrease of hepatic GSH was more severe and prolonged than in the fed rat. Cimetidine was shown to be a potent inhibitor of gastric ADH. Pre-treatment with Cimetidine did not change the basal levels of hepatic GSH, but after oral ethanol load, the decrease of the hepatic GSH content was significantly (p < 0.005) more pronounced than in controls. This study demonstrates the beneficial effects of gastric ethanol metabolism on the liver. The reduced gastric ethanol metabolism, induced by fasting or by Cimetidine resulted in a decreased content and delayed recovery of liver GSH content.
机译：由于一部分摄入的乙醇被胃粘膜代谢，当通过口服或静脉内途径给予相同剂量的酒精时，不同量的酒精应到达肝脏。因此，我们调查了大鼠腹腔内或胃内负荷相同量乙醇后肝脏还原型谷胱甘肽（GSH）浓度随时间变化的过程。该试验还在禁食和西咪替丁治疗的大鼠中进行。与腹膜内给药后相比，口服乙醇给药后GSH的肝脏含量下降不明显，肝脏中的GSH含量恢复较快。在禁食的大鼠中，基础肝谷胱甘肽显着降低。饮酒后，肝脏GSH的下降比进食的大鼠更为严重和延长。西咪替丁被证明是胃ADH的有效抑制剂。西咪替丁的预处理未改变肝脏GSH的基础水平，但口服乙醇负荷后，肝脏GSH含量的降低比对照组显着（p <0.005）。这项研究证明了胃乙醇代谢对肝脏的有益作用。禁食或西咪替丁引起的胃乙醇代谢降低导致肝脏GSH含量降低和恢复延迟。

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