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首页> 外文期刊>Life sciences >Protective effect of ginseng extract against apoptotic cell death induced by 2,2',5,5'-tetrachlorobiphenyl in neuronal SK-N-MC cells.
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Protective effect of ginseng extract against apoptotic cell death induced by 2,2',5,5'-tetrachlorobiphenyl in neuronal SK-N-MC cells.

机译：人参提取物对神经元SK-N-MC细胞中2,2'，5,5'-四氯联苯诱导的凋亡细胞死亡的保护作用。

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摘要

Oxidative stress plays an important role in the pathological processes of neurodegenerative diseases. Polychlorinated biphenyls (PCBs) are ubiquitous environmental contaminants, some of which may be neurotoxic. 2,2',5,5'-Tetrachlorobiphenyl (PCB 52) induces apoptotic death in human neuronal SK-N-MC cells, as demonstrated by gel electrophoresis, which demonstrates the proteolytic cleavage of beta-catenin and poly(ADP-ribose) polymerase (PARP) and the characteristic ladder patterns of DNA fragmentation. In the present study, we investigated whether Panax ginseng extract protect human neuronal SK-N-MC cells from PCB 52-induced apoptosis. The addition of 500 microg/ml of ginseng extract to a culture medium significantly protected neuronal cell from the apoptosis mediated by PCB 52 and remarkably attenuated lipid peroxidation, the generation of reactive oxygen species, and DNA fragmentation, and markedly reduced the PCB 52 induced proteolytic cleavage of beta-catenin and PARP. These results show that Panax ginseng extract protects human neuronal SK-N-MC cells from the apoptosis induced by PCB 52. We suggest that Panax ginseng extracts may protect neuronal cells from oxidative injury.
机译：氧化应激在神经退行性疾病的病理过程中起重要作用。多氯联苯（PCB）是普遍存在的环境污染物，其中一些可能具有神经毒性。 2,2'，5,5'-四氯联苯（PCB 52）诱导人神经元SK-N-MC细胞凋亡，如凝胶电泳所示，它证明了β-catenin和聚（ADP-核糖）的蛋白水解作用聚合酶（PARP）和DNA片段化的特征阶梯模式。在本研究中，我们调查了人参提取物是否能保护人神经元SK-N-MC细胞免受PCB 52诱导的细胞凋亡。向培养基中添加500微克/毫升人参提取物可显着保护神经元细胞免受PCB 52介导的凋亡，并显着减弱脂质过氧化作用，活性氧的产生和DNA片段化，并显着降低PCB 52诱导的蛋白水解作用β-连环蛋白和PARP的裂解。这些结果表明人参提取物可以保护人神经元SK-N-MC细胞免受PCB 52诱导的细胞凋亡。我们建议人参提取物可以保护神经元细胞免受氧化损伤。

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