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An electrophysiological evaluation of serotonergic dorsal raphe neurons in Maudsley rats.

机译:Maudsley大鼠中血清素能背背沟神经元的电生理评估。

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Extracellular electrophysiological recording techniques were used to study serotonergic dorsal raphe (DRN) neurons in Maudsley Reactive (MR), Maudsley Non-Reactive (MNRA) and Sprague Dawley (SD; reference control strain) rats. No significant differences were observed in the average discharge rates of DRN neurons from SD, MR AND MNRA rats. The sensitivity of DRN neuron somatodendritic 5-HT1A autoreceptors to the inhibitory effects of i.v. 8-OH-DPAT or alpha 1-adrenoceptors to the excitatory effects of iontophoretic phenylephrine did not differ significantly among strains. These findings are discussed in light of the previously reported strain-dependent differences in anxiety-like behavior and noradrenergic locus coeruleus neurons.
机译:细胞外电生理记录技术用于研究Maudsley反应性(MR),Maudsley非反应性(MNRA)和Sprague Dawley(SD;参考对照品系)大鼠的血清素能背脊(DRN)神经元。 SD,MR和MNRA大鼠的DRN神经元的平均排出率没有显着差异。 DRN神经元体树突状5-HT1A自身受体对静脉抑制作用的敏感性。离子电渗去氧肾上腺素的兴奋作用的8-OH-DPAT或α1-肾上腺素受体之间没有显着差异。根据先前报道的焦虑样行为和去甲肾上腺素能蓝斑神经元神经元的应变依赖性差异讨论了这些发现。

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