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Structure-radical scavenging activity relationships of phenolic compounds from traditional Chinese medicinal plants

机译：中草药中酚类化合物的自由基清除活性关系

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Traditional Chinese medicinal plants associated with anticancer contain a wide variety of natural phenolic compounds with various structural features and possessing widely differing antioxidant activity. The structure-radical scavenging activity relationships of a large number of representative phenolic compounds (e.g., flavanols, flavonols, chalcones, flavones, flavanones, isoflavones, tannins, stilbenes, curcuminoids, phenolic acids, coumarins, lignans, and quinones) identified in the traditional Chinese medicinal plants were evaluated using the improved ABTS(.+) and DPPH methods. Different categories of tested phenolics showed significant mean differences in radical scavenging activity. Tannins demonstrated the strongest activity, while most quitiones, isoflavones, and lignans tested showed the weakest activity. This study confirmed that the number and position of hydroxyl groups and the related glycosylation and other substitutions largely determined radical scavenging activity of the tested phenolic compounds. The differences in radical scavenging activity were attributed to structural differences in hydroxylation, glycosylation and methoxylation. The ortho-dihydroxy groups were the most important structural feature of high activity for all tested phenolic compounds. Other structural features played a modified role in enhancing or reducing the activity. Within each class of phenolic compounds, the structure-activity relationship was elucidated and discussed. This study reveals the structure-activity relationships of a large series of representative natural phenolic compounds more systematically and fully than previous work. Structure-radical scavenging activity relationships of some natural phenolics identified in the medicinal plants were evaluated for the first time. (c) 2005 Elsevier Inc. All rights reserved.
机译：与抗癌相关的传统中草药植物含有多种具有各种结构特征并且具有广泛不同的抗氧化活性的天然酚类化合物。在传统方法中鉴定出的大量代表性酚类化合物（例如黄烷醇，黄酮醇，查尔酮，黄酮，黄烷酮，异黄酮，丹宁酸，芪，姜黄素，酚酸，香豆素，木脂素和醌）的结构自由基清除活性关系使用改良的ABTS（。+）和DPPH方法对中草药进行了评估。不同类别的测试酚类化合物在自由基清除活性上显示出显着的平均差异。单宁显示出最强的活性，而测试的大多数蛋清，异黄酮和木脂素显示出最弱的活性。这项研究证实，羟基的数量和位置以及相关的糖基化和其他取代在很大程度上决定了所测试酚类化合物的自由基清除活性。自由基清除活性的差异归因于羟基化，糖基化和甲氧基化的结构差异。对于所有测试的酚类化合物，邻二羟基是高活性最重要的结构特征。其他结构特征在增强或减少活性方面起了修改的作用。在每一类酚类化合物中，都阐明并讨论了结构-活性关系。这项研究比以前的工作更加系统和全面地揭示了一系列代表性的天然酚类化合物的构效关系。首次评估了在药用植物中鉴定出的某些天然酚类化合物的结构自由基清除活性关系。 （c）2005 Elsevier Inc.保留所有权利。

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