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首页> 外文期刊>Life sciences >Heroin affects purine nucleotides catabolism in rats in vivo.
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Heroin affects purine nucleotides catabolism in rats in vivo.

机译：海洛因在体内影响嘌呤核苷酸的分解代谢。

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摘要

To investigate the effect of heroin on purine nucleotides catabolism, a rat model of heroin administration and withdrawal was established. Concentrations of uric acid, creatinine, and urea nitrogen in plasma and ADA in plasma, brain, liver, and small intestine were tested. When two heroin administration groups were compared with the control group, the concentrations of plasma uric acid and ADA in plasma, brain, liver, and small intestine increased, whereas the plasma urea nitrogen concentrations in two heroin administration groups and the plasma creatinine concentration in the 3-day heroin administration group did not increase. It seemed that heroin exposure for a short time did not affect renal clearance rate notably. When two withdrawal groups were compared with two heroin administration groups, the concentrations of plasma uric acid and ADA in liver and small intestine decreased, but there was no significant reduction in ADA concentrations of the brain, while the plasma ADA concentrations in the twowithdrawal groups were significantly higher than those of two heroin administration groups. When the two withdrawal groups were compared with the control group, there was no significant difference in the concentrations of plasma uric acid and ADA in liver and small intestine, while the concentrations of ADA in plasma and brain were still higher than those of the control group. The results imply that heroin administration may enhance the catabolism of purine nucleotides in the brain and other tissues by increased concentration of ADA and the effect may last for a long time in the brain.
机译：为了研究海洛因对嘌呤核苷酸分解代谢的影响，建立了海洛因给药和戒断的大鼠模型。测试了血浆，脑，肝和小肠中尿酸，肌酐和尿素氮的浓度以及ADA。当将两个海洛因给药组与对照组进行比较时，血浆，脑，肝和小肠中血浆尿酸和ADA的浓度增加，而两个海洛因给药组中血浆尿素氮浓度和血浆肌酐浓度在对照组中升高。 3天海洛因管理组未增加。短时间内接触海洛因似乎对肾脏清除率没有明显影响。当将两个戒断组与两个海洛因给药组进行比较时，肝脏和小肠中血浆尿酸和ADA的浓度降低，但大脑的ADA浓度没有显着降低，而两个戒断组的血浆ADA浓度为明显高于两个海洛因管理组。当两个戒断组与对照组比较时，肝脏和小肠中血浆尿酸和ADA的浓度没有显着差异，而血浆和脑中ADA的浓度仍高于对照组。结果表明，海洛因的给药可以通过增加ADA的浓度来增强脑和其他组织中嘌呤核苷酸的分解代谢，并且这种作用在脑中可能持续很长时间。

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