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首页> 外文期刊>Life sciences >Prolactin induces phosphorylation of the STAT5 in adrenal glands of Hatano rats during stress.
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Prolactin induces phosphorylation of the STAT5 in adrenal glands of Hatano rats during stress.

机译：催乳素在应激期间诱导Hatano大鼠肾上腺中STAT5的磷酸化。

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AIMS: To investigate the signaling of prolactin (PRL) in the adrenal gland during stress in Hatano high- (HAA) and low-avoidance (LAA) rats. MAIN METHODS: Adrenal glands of both strains were collected at 0, 15 and 30 min after stress. The protein levels of phosphorylated STAT5 and the mRNA levels of melanocortin receptor 2 (MC2R) and PRL receptor (PRLR) were analyzed. Furthermore, the effects of bromocriptine-induced hypoprolactinemia on adrenocortical responses to stress were investigated. KEY FINDINGS: Adrenocorticotropic hormone (ACTH) concentrations in HAA were greater than LAA, while the difference in PRL concentrations were found only at 120 min after stress induction. No strain differences were observed in corticosterone or progesterone in response to stress. The stress-induced increase in MC2R mRNA expression was higher in HAA, but there was a lowered PRLR mRNA expression. STAT5 become highly phosphorylated in response to stress in both strains, but bromocriptine led to a reduction the STAT5 phosphorylation. Exposure to bromocriptine was associated with a reduction in plasma PRL in response to stress in both strains, while the ACTH levels were not altered. However, the decrease in corticosterone and progesterone in response to stress was observed only in bromocriptine-treated LAA rats. SIGNIFICANCE: These data show that PRL plays an important role in the regulation of corticosterone and progesterone release in LAA but not in HAA during stress. These results suggest that PRL increase in response to stress, and it acts on the adrenal cortex and thereby plays an important physiologic role in protecting against acute stress.
机译：目的：研究波多野高（HAA）和低回避（LAA）大鼠在应激期间肾上腺泌乳素（PRL）的信号传导。主要方法：在应激后0、15和30分钟收集两种菌株的肾上腺。分析了磷酸化STAT5的蛋白水平以及黑皮质素受体2（MC2R）和PRL受体（PRLR）的mRNA水平。此外，还研究了溴隐亭诱导的泌乳素不足对肾上腺皮质应激反应的影响。主要发现：HAA中的促肾上腺皮质激素（ACTH）浓度高于LAA，而PRL浓度的差异仅在诱发压力后120分钟时才发现。响应压力，在皮质酮或孕酮中未观察到应变差异。应激诱导的HAA中MC2R mRNA表达的增加较高，但PRLR mRNA表达降低。 STAT5在两种菌株中均响应应激而变得高度磷酸化，但溴隐亭导致STAT5磷酸化降低。在两种菌株中，暴露于溴隐亭都与血浆PRL的降低相关，以应对压力，而ACTH水平没有改变。但是，仅在用溴隐亭治疗的LAA大鼠中观察到了皮质醇和孕激素对应激的反应减少。意义：这些数据表明，PRL在应激过程中在LAA而不是HAA的皮质酮和孕酮释放的调节中起重要作用。这些结果表明，PRL响应压力而增加，并且作用于肾上腺皮质，从而在防止急性应激中起重要的生理作用。

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