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Antidepressant-like behavioral and neurochemical effects of the citrus-associated chemical apigenin

机译：柑橘类化学芹菜素的抗抑郁样行为和神经化学作用

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Apigenin is one type of bioflavonoid widely found in citrus fruits, which possesses a variety of pharmacological actions on the central nervous system. A previous study showed that acute intraperitoneal administration of apigenin had antidepressant-like effects in the forced swimming test (FST) in ddY mice. To better understand its pharmacological activity, we investigated the behavioral effects of chronic oral apigenin treatment in the FST in male ICR mice and male Wistar rats exposed to chronic mild stress (CMS). The effects of apigenin on central monoaminergic neurotransmitter systems, the hypothalamic-pituitary-adrenal (HPA) axis and platelet adenylyl cyclase activity were simultaneously examined in the CMS rats. Apigenin reduced immobility time in the mouse FST and reversed CMS-induced decrease in sucrose intake of rats. Apigenin also attenuated CNM-induced alterations in serotonin (5-HT), its metabolite 5-hydroxyindoleacetic acid (5-HIAA), dopamine (DA) levels and 5-HIAA/5-HT ratio in distinct rat brain regions. Moreover, apigenin reversed CMS-induced elevation in serum corticosterone concentrations and reduction in platelet adenylyl cyclase activity in rats. These results suggest that the antidepressant-like actions of oral apigenin treatment could be related to a combination of multiple biochemical effects and might help to elucidate its mechanisms of action that are involved in normalization of stress-induced changes in brain monoamine levels, the HPA axis, and the platelet adenylyl cyclase activity. (c) 2008 Elsevier Inc. All rights reserved.
机译：芹菜素是一种广泛存在于柑橘类水果中的生物类黄酮，对中枢神经系统具有多种药理作用。先前的研究表明，腹腔注射芹菜素在ddY小鼠的强迫游泳试验（FST）中具有抗抑郁样作用。为了更好地了解其药理活性，我们调查了长期口服芹菜素治疗在FST中暴露于慢性轻度应激（CMS）的雄性ICR小鼠和雄性Wistar大鼠的行为效应。同时检查了CMS大鼠中芹菜素对中枢单胺能神经递质系统，下丘脑-垂体-肾上腺（HPA）轴和血小板腺苷酸环化酶活性的影响。芹菜素减少了小鼠FST的固定时间，并逆转了CMS诱导的大鼠蔗糖摄入量的减少。芹菜素还减弱了CNM诱导的5-羟色胺（5-HT），其代谢物5-羟吲哚乙酸（5-HIAA），多巴胺（DA）水平和5-HIAA / 5-HT比在不同大鼠脑区域的变化。此外，芹菜素逆转了CMS诱导的大鼠血清皮质酮浓度升高和血小板腺苷酸环化酶活性降低。这些结果表明口服芹菜素治疗的抗抑郁样作用可能与多种生化作用的组合有关，并可能有助于阐明其作用机制，这些作用机制涉及应激诱导的脑单胺水平（HPA轴）的正常化。 ，以及血小板腺苷酸环化酶活性。 （c）2008 Elsevier Inc.保留所有权利。

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