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Inhibitory effect of ginger (Zingiber officinale) on rat ileal motility in vitro

机译：生姜在体外对大鼠回肠运动的抑制作用

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摘要

Ginger (Zingiber officinale rhizome) is a widespread herbal medicine mainly used for the treatment of gastrointestinal diseases, including dyspepsia, nausea and diarrhoea. In the present study we evaluated the effect of this herbal remedy on the contractions induced by electrical stimulation (EFS) or acetylcholine in the isolated rat ileum. Ginger (0.01 - 1000 mug/ml) inhibited both EFS- and acetylcholine-evoked contractions, being more potent in inhibiting the contractions induced by EFS. The depressant effect of ginger on EFS-induced contractions was reduced by the vanilloid receptor antagonist capsazepine (10(-5) M), but unaffected by the alpha(2)-adrenergic antagonist yohimbine (10(-7) M), the CB1 receptor antagonist SR141716A (10(-6) M), the opioid antagonist naloxone (10-6 M) or by the NO synthase inhibitor L-NAME (3 X 10(-4) M). Zingerone (up to 3 X 10(-4) M), one of the active ingredients of ginger, did not possess inhibitory effects. It is concluded that ginger possesses both prejunctional and postjunctional inhibitory effects on ileal contractility; the prejunctional inhibitory effect of ginger on enteric excitatory transmission could involve a capsazepine-sensible site (possibly vanilloid receptors). (C) 2004 Elsevier Inc. All rights reserved.
机译：生姜（Zingiber officinale rhizome）是一种广泛使用的草药，主要用于治疗胃肠道疾病，包括消化不良，恶心和腹泻。在本研究中，我们评估了该草药对离体大鼠回肠中电刺激（EFS）或乙酰胆碱引起的收缩的影响。生姜（0.01-1000杯/毫升）抑制EFS和乙酰胆碱引起的收缩，在抑制EFS诱导的收缩方面更有效。香草类受体拮抗剂卡塞平（10（-5）M）降低了姜对EFS诱导的收缩的抑制作用，但不受α（2）-肾上腺素拮抗剂育亨宾（10（-7）M），CB1的影响受体拮抗剂SR141716A（10（-6）M），阿片类拮抗剂纳洛酮（10-6 M）或NO合酶抑制剂L-NAME（3 X 10（-4）M）。姜汁中的有效成分之一姜油酮（最多3 X 10（-4）M）没有抑制作用。结论是生姜对回肠收缩性具有结前和结后抑制作用。生姜对肠内兴奋性传递的抑制作用可能涉及辣椒碱敏感的部位（可能是类香草酸受体）。 （C）2004 Elsevier Inc.保留所有权利。

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