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首页> 外文期刊>Life sciences >Water extract of the root of Lindera strychnifolia slows down the progression of diabetic nephropathy in db/db mice.
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Water extract of the root of Lindera strychnifolia slows down the progression of diabetic nephropathy in db/db mice.

机译：Linder strychnifolia根的水提取物可减慢db / db小鼠的糖尿病肾病的进程。

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摘要

We examined a possible preventive effect of Linderae radix (LR), the root of Lindera strychnifolia, on the progression of diabetic nephropathy. Water extract of Linderae radix (LR extract) was orally administered to the C57BL/KsJ-db/db (db/db) mice, a model of genetic diabetes, at a dose of 730 mg/kg/day for 12 week. The LR extract treatment did not affect glucose metabolism and systolic pressure. However, it resulted in a better renal function as evaluated by creatinine clearance (Ccr) and serum creatinine than the control; Ccr and serum creatinine were progressively worsened in controls (0.13+/-0.01 (l/day) and 0.69+/-0.04 (mg/dl), respectively) whereas unchanged in the treated group (0.24+/-0.03 (l/day), p<0.05 and 0.53+/-0.04 (mg/dl), p<0.05, respectively). Kidneys of the LR extract-treated group showed glomeruli with greater area and cell population, smaller glomerular sclerotic index, and less fibrosis in glomeruli, where apoptotic rate of glomerular cells were decreased compared with the controlkidneys. Furthermore, renal TGF-beta(1) expression was decreased in the LR extract-treated group. These findings suggest that the LR therapy can be a novel therapeutic approach against diabetic nephropathy.
机译：我们检查了Lindere strychnifolia的根Lindere radix（LR）对糖尿病性肾病的可能预防作用。以730 mg / kg / day的剂量口服Linderae radix的水提取物（LR提取物）12天，剂量为730 mg / kg / day，这是遗传性糖尿病模型C57BL / KsJ-db / db（db / db）小鼠。 LR提取物处理不影响葡萄糖代谢和收缩压。然而，通过肌酐清除率（Ccr）和血清肌酐评估，与对照相比，肾功能更好。对照组的Ccr和血清肌酐逐渐恶化（分别为0.13 +/- 0.01（l / day）和0.69 +/- 0.04（mg / dl）），而在治疗组中则不变（0.24 +/- 0.03（l / day） ），p <0.05和0.53 +/- 0.04（mg / dl），p <0.05）。 LR提取物治疗组的肾脏显示肾小球的面积和细胞数量更大，肾小球硬化指数较小，肾小球的纤维化较少，与对照组相比，肾小球细胞的凋亡率降低。此外，LR提取物治疗组的肾TGF-β（1）表达降低。这些发现表明，LR疗法可以是针对糖尿病性肾病的新型治疗方法。

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