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Hydrogen peroxide scavenging activity by non-steroidal anti-inflammatory drugs

机译：非甾体类抗炎药清除过氧化氢的活性

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摘要

Hydrogen peroxide (H2O2) has been shown to be formed during inflammatory processes and is implicated in its pathophysiology. Thus, a putative scavenging activity against this reactive oxygen specie (ROS) by anti-inflammatory drugs may be of great therapeutical value. The present study was undertaken to evaluate the scavenging activity for H2O2 by several non-steroidal anti -inflammatory drugs (NSAIDs), namely indomethacin, acemetacin, etodolac, tolmetin, ketorolac, oxaprozin, sulindac and its metabolites sulindac sulfide and sulindac sulfone. The H2O2 scavenging assay was performed by measuring H2O2-elicited lucigenin chemiluminescence using a microplate reader. The specificity of the method was confirmed by the use of catalase, which completely prevented the H2O2-induced lucigenin chemiluminescence. The endogenous antioxidants melatonin and reduced glutathione (GSH) were used as positive controls. The obtained results demonstrated that all the studied NSAIDs display H2O2, scavenging activity, although in different extents. The ranking order of potency found was sulindac sulfeme > sulindac sulfide > GSH > sulindac > indomethacin > acemetacin > etodolac > oxaprozin > ketorolac approximate to melatonin > tolmetin. (c) 2005 Elsevier Inc. All rights reserved.
机译：已显示过氧化氢（H2O2）在炎症过程中形成，并与其病理生理学有关。因此，通过抗炎药对这种活性氧物种（ROS）的假定清除活性可能具有巨大的治疗价值。进行本研究以评估几种非甾体抗炎药（NSAID）对H2O2的清除活性，这些消炎药是消炎痛，醋乙酰胺，依托度酸，托美丁，酮咯酸，奥沙普嗪，舒林酸及其代谢产物舒林酸硫化物和舒林酸砜。通过使用酶标仪测量H2O2引起的黄精蛋白化学发光来进行H2O2清除测定。过氧化氢酶的使用证实了该方法的特异性，过氧化氢酶完全阻止了H2O2诱导的光泽素化学发光。内源性抗氧化剂褪黑激素和还原型谷胱甘肽（GSH）用作阳性对照。获得的结果表明，所有研究的NSAIDs都具有H2O2清除活性，尽管程度不同。发现的效能的排名顺序为：舒林酸>舒林酸>舒林酸> GSH>舒林酸>消炎痛>醋美他汀>依托度酸>奥沙普嗪>酮咯酸，近似于褪黑激素>托美汀。 （c）2005 Elsevier Inc.保留所有权利。

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