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首页> 外文期刊>Life sciences >Effects of oral consumption of the green tea polyphenol EGCG in a murine model for human Sjogren's syndrome, an autoimmune disease.
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Effects of oral consumption of the green tea polyphenol EGCG in a murine model for human Sjogren's syndrome, an autoimmune disease.

机译：口服食用绿茶多酚EGCG对人干燥综合征（一种自身免疫性疾病）的鼠模型的影响。

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SIGNIFICANCE: Protection of glandular cells from autoimmune-induced damage would be of significant clinical benefit to Sjogren's syndrome (SS) patients. Epigallocatechin-3-gallate (EGCG) possesses anti-apoptotic, anti-inflammatory, and autoantigen-inhibitory properties. AIMS: To investigate if EGCG protects against certain autoimmune-induced pathological changes in the salivary glands of the non-obese diabetic (NOD) mouse model for SS. MAIN METHODS: Animals were provided with either water or water containing 0.2% EGCG. At the age of 8, 16 and 22 weeks, submandibular salivary gland tissue and serum samples were collected for pathological and serological analysis. KEY FINDINGS: Significant lymphocyte infiltration was observed in the salivary glands of the water-fed group at the age of 16 weeks, while the EGCG group showed reduced lymphocyte infiltration. By 22 weeks of age, water-fed animals demonstrated elevated levels of apoptotic activity within the lymphocytic infiltrates, and high levels of serum total anti-nuclear antibody, compared to EGCG-fed animals. Remarkably, proliferating cell nuclear antigen (PCNA) and Ki-67 levels in the salivary glands of water-fed NOD mice were significantly elevated in comparison to BALB/c control mice; in contrast, PCNA and Ki-67 levels in EGCG-fed NOD animals were similar to BALB/c mice. These results indicate that EGCG protects the NOD mouse submandibular glands from autoimmune-induced inflammation, and reduces serum autoantibody levels. Abnormal proliferation, rather than apoptosis, appears to be a characteristic of the NOD mouse gland that is normalized by EGCG. The evidence suggests that EGCG could be useful in delaying or managing SS-like autoimmune disorders.
机译：意义：保护腺细胞免于自身免疫引起的损害，对于干燥综合征（SS）患者具有重要的临床意义。表没食子儿茶素-3-没食子酸酯（EGCG）具有抗凋亡，抗炎和抑制自身抗原的特性。目的：研究EGCG是否能预防SS的非肥胖糖尿病（NOD）小鼠模型唾液腺中某些自身免疫性病理改变。主要方法：给动物提供水或含0.2％EGCG的水。在8、16和22周龄时，收集下颌下唾液腺组织和血清样品进行病理和血清学分析。主要发现：16周龄时，在水喂养组的唾液腺中观察到明显的淋巴细胞浸润，而EGCG组显示淋巴细胞浸润减少。与EGCG喂养的动物相比，到22周大时，水喂养的动物在淋巴细胞浸润液中的凋亡活性水平升高，血清总抗核抗体水平升高。值得注意的是，与BALB / c对照小鼠相比，水饲NOD小鼠唾液腺中的增殖细胞核抗原（PCNA）和Ki-67水平显着升高。相反，EGCG喂养的NOD动物中PCNA和Ki-67的水平与BALB / c小鼠相似。这些结果表明，EGCG可保护NOD小鼠下颌下腺免于自身免疫诱导的炎症，并降低血清自身抗体水平。异常增殖而不是凋亡似乎是被EGCG归一化的NOD小鼠腺体的特征。有证据表明，EGCG可能有助于延缓或控制SS样自身免疫性疾病。

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