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首页> 外文期刊>Life sciences >Deletion of p75NTR impairs regeneration of peripheral nerves in mice.
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Deletion of p75NTR impairs regeneration of peripheral nerves in mice.

机译：p75NTR的缺失损害小鼠周围神经的再生。

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AIMS: After peripheral nerve injury, p75NTR was upregulated in Schwann cells of the Wallerian degenerative nerves and in motor neurons but down-regulated in the injured sensory neurons. As p75NTR in neurons mediates signals of both neurotrophins and inhibitory factors, it is regarded as a therapeutic target for the treatment of neurodegeneration. However, its physiological function in the nerve regeneration is not fully understood. In the present study, we aimed to examine the role of p75NTR in the regeneration of peripheral nerves. MAIN METHODS: In p75NTR knockout mice (exon III deletion), the sciatic nerves and facial nerves on one side were crushed and regenerating neurons in the facial nuclei and in the dorsal root ganglia were labelled by Fast Blue. The regenerating fibres in the sciatic nerve were also labelled by an anterograde tracer and by immunohistochemistry. KEY FINDINGS: The results showed that the axonal growth of injured axons in the sciatic nerve of p75NTR mutant mice was significantly retarded. The number of regenerated neurons in the dorsal root ganglia and in the facial nuclei in p75NTR mutant mice was significantly reduced. Immunohistochemical staining of regenerating axons also showed the reduction in nerve regeneration in p75NTR mutant mice. SIGNIFICANCE: Our data suggest that p75NTR plays an important role in the regeneration of injured peripheral nerves.
机译：目的：周围神经损伤后，p75NTR在Wallerian变性神经的Schwann细胞和运动神经元中上调，但在受伤的感觉神经元中下调。由于神经元中的p75NTR介导神经营养蛋白和抑制因子的信号，因此被认为是治疗神经变性的治疗靶标。然而，其在神经再生中的生理功能尚未完全被理解。在本研究中，我们旨在检查p75NTR在周围神经再生中的作用。主要方法：在p75NTR基因敲除小鼠（外显子III缺失）中，将一侧的坐骨神经和面神经压碎，并用Fast Blue标记面部核和背根神经节中的再生神经元。坐骨神经中的再生纤维也通过顺行示踪剂和免疫组织化学标记。关键结果：结果表明，p75NTR突变小鼠的坐骨神经中受损轴突的轴突生长受到了显着抑制。 p75NTR突变小鼠的背根神经节和面核中的再生神经元数量明显减少。再生轴突的免疫组织化学染色也显示p75NTR突变小鼠的神经再生减少。意义：我们的数据表明p75NTR在受伤的周围神经再生中起重要作用。

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