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首页> 外文期刊>Life sciences >Morphine reduces pulmonary inflammation in response to influenza infection
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Morphine reduces pulmonary inflammation in response to influenza infection

机译：吗啡可减轻因流感感染引起的肺部炎症

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The present study shows that morphine reduces the pulmonary inflammatory response to intranasal influenza virus infection in rats. Rats were infected with rat-adapted influenza virus (RAIV), which is a unique infectious agent because normal rats develop an acute pulmonary inflammatory response to RAIV and rapidly clear the virus within a few days with no mortality. Male Lewis rats were implanted with 75mg morphine pellets or placebo pellets 72 hours prior to intranasal RAIV infection. Rats were euthanized at 2, 24, 48, 72, and 96 hours after infection. Assessment of inflammation included accumulation of inflammatory cells in the lungs, lung weight, and protein and LDH content of bronchial alveolar lavage fluid (BALF). Placebo-treated rats showed a marked inflammatory response to RAIV infection, and morphine-treated rats mounted less vigorous inflammatory responses to the infection. Taken together, these data suggest that morphine treatment impairs the inflammatory response to RAIV infection in the lungs, which is consistent with prior work demonstrating that morphine is a potent anti-inflammatory agent in other areas of the body.
机译：本研究表明吗啡可降低大鼠鼻内流感病毒感染的肺部炎症反应。大鼠感染了适应大鼠的流感病毒（RAIV），这是一种独特的传染因子，因为正常大鼠对RAIV会产生急性肺部炎症反应，并在几天之内迅速清除该病毒，而无死亡。在鼻内RAIV感染前72小时，将雄性Lewis大鼠植入75mg吗啡药丸或安慰剂药丸。在感染后2、24、48、72和96小时对大鼠实施安乐死。炎症评估包括肺中炎症细胞的积聚，肺重量以及支气管肺泡灌洗液（BALF）的蛋白质和LDH含量。安慰剂治疗的大鼠对RAIV感染表现出明显的炎症反应，吗啡治疗的大鼠对感染的炎症反应较弱。综上所述，这些数据表明吗啡治疗会损害肺部对RAIV感染的炎症反应，这与先前的研究表明吗啡在人体其他部位是有效的消炎药是一致的。

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