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首页> 外文期刊>Life sciences >Lymphocyte subpopulations, cytokines and trace elements in asymptomatic atopic women exposed to an urban environment.
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Lymphocyte subpopulations, cytokines and trace elements in asymptomatic atopic women exposed to an urban environment.

机译：暴露于城市环境的无症状异位妇女的淋巴细胞亚群，细胞因子和微量元素。

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This study evaluates the immune response to exposure to an urban environment from 30 non-atopic and 30 non-symptomatic women with history of respiratory and/or cutaneous allergies. Blood lymphocyte subsets and serum interleukin (IL) 4 and interferon gamma (INF-gamma) of the two groups were similar, while serum IgE and "in vitro" production of IL-4 and INF-gamma by mononuclear blood cells of the atopic women were higher spontaneously or in the presence of PHA, respectively. Blood lead of the nonatopic women (mean 55 microg/l) was positively correlated with CD4+-CD45RO-, CD3+-CD8+ and CD3--HLA-DR+ lymphocyte subsets, while urinary trans-trans muconic acid (a metabolite of benzene) of both groups of women (mean about 50 microg/l) was significantly correlated with NK CD16+CD56+ lymphocytes. Urine chromium of the non-atopic subjects was significantly correlated with activated T, B and NK HLA-DR+ cells. Urine nickel of both groups of women was correlated with CD4+-CD45RO+ "memory" lymphocytes and their ratio with CD4+-CD45RO- "virgin" lymphocytes suggesting that the metal enhances maturation of "virgin" into "memory" lymphocytes. On the whole, this study demonstrates that exposure to low levels of toxic agents, produced by vehicular traffic in an urban environment, exerts effects on immune functions of women.
机译：这项研究评估了30名无呼吸道过敏和/或皮肤过敏史的非过敏性和30名无症状女性对暴露于城市环境的免疫反应。两组的血淋巴细胞亚群和血清白细胞介素（IL）4和干扰素γ（INF-γ）相似，而异位妇女的单核血细胞的血清IgE和“体外”产生IL-4和INF-γ分别自发或存在PHA时较高。非特应性女性的血铅（平均55微克/升）与CD4 + -CD45RO-，CD3 + -CD8 +和CD3--HLA-DR +淋巴细胞亚组呈正相关，而尿液中的反式-反-粘康酸（苯的代谢物）妇女组（平均约50微克/升）与NK CD16 + CD56 +淋巴细胞显着相关。非特应性受试者的尿铬与活化的T，B和NK HLA-DR +细胞显着相关。两组女性的尿镍均与CD4 + -CD45RO +“记忆”淋巴细胞相关，并且它们与CD4 + -CD45RO-“原始”淋巴细胞的比例相关，这表明金属可增强“原始”成“记忆”淋巴细胞的成熟度。总体而言，这项研究表明，暴露于城市环境中车辆通行产生的低水平毒物，会对女性的免疫功能产生影响。

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