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首页> 外文期刊>Life sciences >A comparative study on the anti-inflammatory, antinociceptive and antipyretic effects of isoquinoline alkaloids from the roots of Turkish Berberis species.
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A comparative study on the anti-inflammatory, antinociceptive and antipyretic effects of isoquinoline alkaloids from the roots of Turkish Berberis species.

机译：土耳其小ber物种根中异喹啉类生物碱的抗炎，镇痛和解热作用的比较研究。

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摘要

Roots and barks of various Berberis species are used as folk remedy for the treatment of various inflammatory diseases such as lumbago, rheumatism and to reduce fever. Six isoquinoline alkaloids namely berberine, berbamine, palmatine, oxyacanthine, magnoflorine, and columbamine were isolated as the main components of alkaloidal fraction from the roots of Turkish Berberis species and effects were studied using various in vivo models in mice. All alkaloids inhibited inflammations in varying degrees, among them berberine, berbamine and palmatine were shown to possess significant and dose-dependent inhibitory activity against serotonin-induced hind paw oedema both on oral and topical applications and acetic acid-induced increase in vascular permeability on oral administration. Moreover, these three alkaloids were also shown to possess dose-dependent antinociceptive activity, which assessed by using the model based on the inhibition of p-benzoquinone-induced writhing movements as well as antipyretic activity on FCA-induced increased rectal temperature on subacute administration. However, all alkaloids induced gastric lesions in varying degrees.
机译：各种小Ber属植物的根和皮被用作民间疗法，以治疗各种炎性疾病，例如腰痛，风湿病和减少发烧。从土耳其小ber物种的根中分离出6种异喹啉碱生物碱，即小ber碱，贝巴明，棕榈碱，氧鸟嘌呤，厚朴碱和哥伦巴胺作为生物碱组分的主要成分，并在小鼠中使用多种体内模型研究了其作用。所有生物碱均在不同程度上抑制炎症，其中小碱，贝巴明和巴马汀在口服和局部应用中均具有显着且剂量依赖性的抑制作用，可抑制5-羟色胺诱导的后爪水肿，以及乙酸诱导的口服血管通透性增加行政。此外，这三种生物碱还显示具有剂量依赖性的抗伤害感受活性，通过使用基于对苯并醌诱导的扭动运动的抑制作用以及亚急性给药时对FCA引起的直肠温度升高的解热活性的模型进行评估。然而，所有生物碱均不同程度地诱导胃损伤。

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