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首页> 外文期刊>Life sciences >Hypoglycemic and hypolipidemic effects and antioxidant activity of fruit extracts from Lycium barbarum.
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Hypoglycemic and hypolipidemic effects and antioxidant activity of fruit extracts from Lycium barbarum.

机译：枸杞子提取物的降血糖和降血脂作用及抗氧化活性。

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摘要

The hypoglycemic and hypolipidemic effects of Lycium barbarum fruit water decoction, crude polysaccharide extracts (crude LBP), and purified polysaccharide fractions (LBP-X) in alloxan-induced diabetic or hyperlipidemic rabbits were investigated through designed sequential trials and by measuring blood glucose and serum lipid parameters. Total antioxidant capacity was also assessed using trolox equivalent antioxidant capacity (TEAC) and oxygen radical absorbance capacity (ORAC) assay. It was found that the three Lycium barbarum fruit extracts/fractions could significantly reduce blood glucose levels and serum total cholesterol (TC) and triglyceride (TG) concentrations and at same time markedly increase high density lipoprotein cholesterol (HDL-c) levels after 10 days treatment in tested rabbits, indicating that there were substantial hypoglycemic and hypolipidemic effects. Hypoglycemic effect of LBP-X was more significant than those of water decoction and crude LBP, but its hypolipidemic effect seemed to be weaker. Total antioxidant capacity assay showed that all three Lycium barbarum extracts/fractions possessed antioxidant activity. However, water and methanolc fruit extracts and crude polysaccharide extracts exhibited stronger antioxidant activity than purified polysaccharide fractions because crude extracts were identified to be rich in antioxidants (e.g., carotenoids, riboflavin, ascorbic acid, thiamine, nicotinic acid). Lycium barbarum polysaccharides (glycocojugates), containing several monosaccharides and 17 amino acids, were major bioactive constituents of hypoglycemic effect. Both polysaccharides and vitamin antioxidants from Lycium barbarum fruits were possible active principles of hypolipidemic effect.
机译：通过设计的连续试验以及测量血糖和血清，研究了枸杞果水煎剂，粗多糖提取物（粗制LBP）和纯化多糖组分（LBP-X）在四氧嘧啶诱导的糖尿病或高脂血症兔中的降血糖和降血脂作用。脂质参数。还使用trolox等效抗氧化剂容量（TEAC）和氧自由基吸收容量（ORAC）分析评估了总抗氧化剂容量。发现三种枸杞果实提取物/馏分可显着降低血糖水平，血清总胆固醇（TC）和甘油三酸酯（TG）浓度，同时在10天后显着增加高密度脂蛋白胆固醇（HDL-c）水平在接受测试的家兔中进行治疗，表明存在明显的降血糖和降血脂作用。 LBP-X的降血糖作用比水煎剂和粗LBP的降血糖作用更显着，但其降血脂作用似乎较弱。总抗氧化能力测定表明，三种枸杞提取物/级分均具有抗氧化活性。然而，水和甲醇水果提取物和粗多糖提取物显示出比纯化的多糖级分更强的抗氧化活性，因为已鉴定出粗提取物富含抗氧化剂（例如，类胡萝卜素，核黄素，抗坏血酸，硫胺素，烟酸）。枸杞多糖（糖共轭物），含有几种单糖和17个氨基酸，是降血糖作用的主要生物活性成分。枸杞果实中的多糖和维生素抗氧化剂都可能是降血脂作用的有效原理。

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