• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Life sciences >Trans fatty acids in hydrogenated fat inhibited the synthesis of the polyunsaturated fatty acids in the phospholipid of arterial cells
【24h】

Trans fatty acids in hydrogenated fat inhibited the synthesis of the polyunsaturated fatty acids in the phospholipid of arterial cells

机译：氢化脂肪中的反式脂肪酸抑制动脉细胞磷脂中多不饱和脂肪酸的合成

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Our hypothesis that the trans fatty acids in hydrogenated fat inhibited the synthesis of polyunsaturated fatty acids in the phospholipid of arterial cells was tested with five groups each with six pregnant porcine fed from d 35 of gestation and during lactation. The basal diet contained 2% corn oil (control). The other four diets included the control + 10% butter or 10% hydrogenated fat plus two levels of Mg. Plasma, milk and aortic phospholipid fatty acids, phospholipid composition and calcium content of the aorta from the piglets were determined. At 48 + 2 d of age, the aorta phospholipid of piglets from porcine fed hydrogenated fat contained a significantly higher concentration of linoleic acid, less arachidonic acid, and less long chain polyunsaturated fatty acid (PUFA) than did piglets from porcine fed either butterfat or the control diet. Mg had no effect. These changes in composition in piglets from porcine fed hydrogenated fat indicate that trans fat inhibits the metabolic conversion of linoleic acid to arachidonic acid and to other n-6 PUFA. The aortic calcium content data showed a significant interaction of calcium concentration with age. We concluded: 1) that dietary trans fat perturbed essential fatty acid (EFA) metabolism which led to changes in the phospholipid fatty acid composition in the aorta, the target tissue of atherogenesis, 2) this inhibition of EFA to PUFA by the isomeric fatty acids in hydrogenated fat is a risk factor in the development of coronary heart disease. (C) 2004 Elsevier Inc. All rights reserved. [References: 43]
机译：我们的假设关于氢化脂肪中的反式脂肪酸抑制了动脉细胞磷脂中多不饱和脂肪酸的合成，我们对五组进行了试验，每组分别从妊娠第35天和哺乳期间喂食了六只怀孕的猪。基础饮食含有2％的玉米油（对照）。其他四种饮食包括对照+ 10％的黄油或10％的氢化脂肪以及两种水平的Mg。测定小猪的血浆，牛奶和主动脉磷脂脂肪酸，磷脂成分和主动脉钙含量。在48 + 2 d龄时，来自猪饲喂的氢化脂肪的仔猪的主动脉磷脂中的亚油酸，花生四烯酸和长链多不饱和脂肪酸（PUFA）的浓度明显高于来自饲喂牛脂或猪脂肪的猪的仔猪。控制饮食。镁没有作用。猪饲喂的氢化脂肪在仔猪中的这些组成变化表明，反式脂肪抑制了亚油酸向花生四烯酸和其他n-6 PUFA的代谢转化。主动脉钙含量数据显示钙浓度与年龄之间存在显着的相互作用。我们得出以下结论：1）饮食中的反式脂肪扰乱了必需脂肪酸（EFA）的代谢，从而导致动脉粥样硬化的目标组织主动脉中的磷脂脂肪酸组成发生了变化，2）这种异构脂肪酸对EFA对PUFA的抑制作用氢化脂肪中的胆固醇是发展冠心病的危险因素。 （C）2004 Elsevier Inc.保留所有权利。 [参考：43]

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号