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首页> 外文期刊>Life sciences >The influence of lead and arsenite on the inhibition of human breast cancer MCF-7 cell proliferation by American ginseng root (Panax quinquefolius L.).
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The influence of lead and arsenite on the inhibition of human breast cancer MCF-7 cell proliferation by American ginseng root (Panax quinquefolius L.).

机译：铅和砷对西洋参（Panax quinquefolius L.）抑制人乳腺癌MCF-7细胞增殖的影响。

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摘要

American ginseng root (Panax quinquefolius) has a number of purported therapeutic effects, including inhibition of cancer cell proliferation. The ability of environmentally relevant heavy metals to alter ginseng effects on cancer cell growth was the subject of this study. A water extract of American ginseng root was applied alone or in combination with physiologically relevant doses of either lead (Pb) or arsenite to MCF-7 breast cancer cells in vitro and effects on cell proliferation were determined. Ginseng alone produced a significant dose-dependent inhibition of MCF-7 cell proliferation starting at 0.5 mg ml(-1). Treatment of MCF-7 cells with 2.5 microM arsenite significantly decreased MCF-7 cell proliferation (p < 0.01). When cells were treated with arsenite (1.25 or 2.5 microM) in combination with ginseng extract (0.5 mg ml(-1)), there was an apparent synergistic inhibition of cell proliferation. Treatment of MCF-7 breast cancer cells with 50 microM Pb significantly decreased cell proliferation relative to control (p < 0.01), and concomitant ginseng and Pb treatment did not lead to a further decrease. These results suggest that contaminant heavy metals, some of which have been detected in ginseng root extracts or commercial ginseng preparations, may alter the biological activity of ginseng.
机译：西洋参（Panax quinquefolius）具有许多声称的治疗作用，包括抑制癌细胞增殖。环境相关重金属改变人参对癌细胞生长的影响的能力是本研究的主题。西洋参根的水提取物单独或与生理相关剂量的铅（Pb）或亚砷酸盐组合应用到体外MCF-7乳腺癌细胞中，并确定了对细胞增殖的影响。从0.5 mg ml（-1）开始，人参单独对MCF-7细胞增殖产生了显着的剂量依赖性抑制作用。用2.5 microM亚砷酸盐处理MCF-7细胞可显着降低MCF-7细胞增殖（p <0.01）。当用砷（1.25或2.5 microM）与人参提取物（0.5 mg ml（-1））联合处理细胞时，明显抑制了细胞增殖。与对照相比，用50 microM Pb处理MCF-7乳腺癌细胞可显着降低细胞增殖（p <0.01），并且人参和Pb的伴随治疗并未导致其进一步降低。这些结果表明，人参根提取物或商业人参制品中已检测到重金属污染物，可能会改变人参的生物活性。

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