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首页> 外文期刊>Life sciences >HETEROGENEITY IN THE PERFORMANCE OF OUTBRED SPRAGUE-DAWLEY RATS IN AN ELEVATED-PLUS MAZE TEST - A POSSIBLE ANIMAL MODEL FOR ANXIETY DISORDER
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HETEROGENEITY IN THE PERFORMANCE OF OUTBRED SPRAGUE-DAWLEY RATS IN AN ELEVATED-PLUS MAZE TEST - A POSSIBLE ANIMAL MODEL FOR ANXIETY DISORDER

机译：加高迷宫试验中超斯普拉格-道利大鼠表现的异质性-一种可能的焦虑症动物模型

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A wide variation in the performance of inbred rats measured in the elevated plus maze test suggests a possible genetic basis for anxiety response (AR). To gain further insight into the role of genetics in AR, we have characterized AR in male outbred S-D rats. Rats were placed in the black compartment (BC) facing the wall opposite the aperture and time needed for the animal to exit BC was noted. All rats underwent 3 successive trials 1-1.5 hrs apart. Naive rats showed a wide variation in their AR in trial 1 (mean=89+/-19 sec, range=5-360 sec). Sixty-eight % of the rats exhibiting low AR exited BC in <30sec, whereas 16% stayed in for the entire 360 sec (high AR). On successive testing, there was a progressive increase in AR which reached to max on second trial (Trial 1: 89+/-19, Trial 2: 171+/-23, Trial 3: 210+/-22 sec, p<0.0001). The time spent in BC on successive trials increased for most rats (33/44), decreased for some (2/44), showed min to no change (5/44) or erratic response (4/44) for others. In conclusion wide variation in the AR in outbred rats could be exploited to study genetic and neurochemical mechanisms of anxiety. [References: 19]
机译：在高架迷宫测试中测得的近交大鼠的表现差异很大，这表明可能存在焦虑反应的遗传基础。为了进一步了解遗传学在AR中的作用，我们在雄性近交S-D大鼠中鉴定了AR。将大鼠放在面对孔的壁对面的黑色隔室（BC）中，并记录了动物退出BC所需的时间。所有大鼠均隔1-1.5小时进行了3次连续试验。在试验1中，幼稚大鼠的AR表现出很大的差异（平均= 89 +/- 19秒，范围= 5-360秒）。表现出低AR的大鼠中有68％在<30秒内退出BC，而在整个360秒内（高AR）则有16％停留在BC中。在连续测试中，AR逐渐增加，在第二次试验中达到最大值（试验1：89 +/- 19，试验2：171 +/- 23，试验3：210 +/- 22秒，p <0.0001 ）。对于大多数大鼠，在连续实验中花费在BC上的时间增加了（33/44），对某些大鼠减少了（2/44），对其他大鼠则显示了从最小到无变化（5/44）或不稳定的响应（4/44）。总之，可以利用远亲大鼠中AR的广泛差异来研究焦虑的遗传和神经化学机制。 [参考：19]

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