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The cannabinoid receptor-2 is involved in allergic inflammation

机译：大麻素受体2参与过敏性炎症

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Aim: To investigate the role of cannabinoid receptor-2 (CB2) in allergic inflammation in CB2 knockout (CB2-KO) mice. Main methods: The swelling reaction of the pinna to various stimuli was compared between CB2-KO and wild-type (WT) mice in terms of edema and acanthosis. Key findings: Ear swelling induced by repeated application of 2,4-dinitrofluorobenzene in CB2-KO mice was significantly decreased compared with that in WT mice. In an ovalbumin model, pinna edema was significantly suppressed in CB2-KO mice in comparison with that in WT mice. The contribution of CB2 to edema was investigated in a more extreme dermatitis model using oxazolone. Delayed-type hypersensitivity reactions in this model were also suppressed in CB2-KO mice. In each of these three different allergic dermatitis models, there was a significant decrease in edema and acanthosis in CB2-KO mice compared with WT mice. Significance: These results clearly demonstrate that CB2 and its endogenous ligands participate not only in the acute, edematous phase of allergic dermatitis, but also in the chronic irreversible acanthosis reaction.
机译：目的：研究大麻素受体2（CB2）在CB2基因敲除（CB2-KO）小鼠过敏性炎症中的作用。主要方法：比较了CB2-KO和野生型（WT）小鼠在水肿和棘皮症中耳廓对各种刺激的肿胀反应。关键发现：与野生型小鼠相比，CB2-KO小鼠反复使用2,4-二硝基氟苯引起的耳肿胀明显降低。在卵清蛋白模型中，与野生型小鼠相比，CB2-KO小鼠的耳廓水肿得到了显着抑制。使用恶唑酮在更极端的皮炎模型中研究了CB2对水肿的贡献。在该模型中的迟发型超敏反应在CB2-KO小鼠中也得到抑制。在这三种不同的过敏性皮炎模型中，与WT小鼠相比，CB2-KO小鼠的水肿和棘皮症显着减少。意义：这些结果清楚地表明，CB2及其内源性配体不仅参与过敏性皮炎的急性水肿期，而且参与慢性不可逆棘皮病反应。

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