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首页> 外文期刊>Life sciences >ASSESSMENT OF DIURNAL VARIATION OF CEREBROSPINAL FLUID TRYPTOPHAN AND 5-HYDROXYINDOLEACETIC ACID IN HEALTHY HUMAN FEMALES
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ASSESSMENT OF DIURNAL VARIATION OF CEREBROSPINAL FLUID TRYPTOPHAN AND 5-HYDROXYINDOLEACETIC ACID IN HEALTHY HUMAN FEMALES

机译：人体健康中脑脊髓液中三苯乙胺和5-羟吲哚乙酸的每日变化评估

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The role of serotonin (5-HT) in the pathogenesis and treatment of major neuropsychiatric disorders, including mood and anxiety disorders, continues to be the subject of extensive research. Previous studies examining central 5-HT functioning measured cerebrospinal fluid (CSF) levels of 5-hydroxyindoleacetic acid (5-HIAA) by using single or multiple lumbar punctures. A number of investigators have demonstrated the feasiblity of continuous CSF sampling via an indwelling lumbar catheter to study CSF neurochemistry in healthy subjects and patients with neuropsychiatric illness. Four healthy female volunteers, aged 21-34 years, underwent continuous CSF sampling. CSF was collected at a constant rate of 1 mi every 10 minutes over a 30-hour period, with levels of tryptophan (TRP) and 5-HIAA measured every hour. Plasma was also obtained hourly for TRP determination. The results of this study indicate that CSF 5-HIAA, CSF TRP, and plasma TRP levels showed variation over time, but failed to show diurnal fluctuation. Intraindividual coefficients of variation determined for CSF 5-HIAA, CSF TRP, and plasma TRP ranged from 9.2 to 14.9%, 8.8 to 14.6%, and 14.7 to 19.0%, respectively. Continuous CSF sampling is safe and feasible in humans, and may prove useful for studies of central 5-HT neurotransmission in neuropsychiatric illness. [References: 47]
机译：血清素（5-HT）在主要神经精神疾病（包括情绪和焦虑症）的发病机理和治疗中的作用仍是广泛研究的主题。以前的研究检查了中央5-HT的功能，通过使用一次或多次腰椎穿刺测量了5-羟吲哚乙酸（5-HIAA）的脑脊液（CSF）水平。许多研究人员证明了通过留置腰椎导管连续进行CSF采样以研究健康受试者和神经精神病患者的CSF神经化学的可行性。四名年龄在21-34岁之间的健康女性志愿者接受了连续的CSF采样。在30小时内，每10分钟以1英里的恒定速率收集CSF，每小时测量一次色氨酸（TRP）和5-HIAA的水平。还每小时获取血浆用于TRP测定。这项研究的结果表明，CSF 5-HIAA，CSF TRP和血浆TRP水平随时间变化，但未显示出昼夜波动。为CSF 5-HIAA，CSF TRP和血浆TRP确定的个体内变异系数分别为9.2％至14.9％，8.8％至14.6％和14.7％至19.0％。连续的CSF采样在人类中是安全可行的，并且可能被证明对神经精神病学中枢5-HT神经传递的研究有用。 [参考：47]

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