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MODULATION OF THE LENGTH OF THE CELL CYCLE TIME OF MCF-7 HUMAN BREAST CANCER CELLS BY MELATONIN

机译:褪黑素对人乳腺癌MCF-7细胞周期时间的调节

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It has been shown that melatonin has a direct inhibitory effect on the proliferation of MCF-7 human breast cancer cells in culture. In the present work, vie studied whether the length of the cell cycle of MCF-7 cells is increased by melatonin. In MCF-7 cells partially synchronized and labelled with [H-3]thymidine, melatonin (10(-9) M), added to the culture medium, shifted the period of the labeling index rhythm from 20.36 hours to 23.48 hours. The fact that melatonin significantly increased (p < 0.005) the duration of the cell cycle of human breast cancer cells, support the notion that this hormone exerts part of its antitumor effect through a cell-cycle-specific mechanism by delaying the entry of MCF-7 cells into mitosis. [References: 31]
机译:已经表明褪黑激素对培养中的MCF-7人乳腺癌细胞的增殖具有直接的抑制作用。在目前的工作中,vie研究了褪黑激素是否会增加MCF-7细胞的细胞周期长度。在部分同步并用[H-3]胸苷标记的MCF-7细胞中,将褪黑激素(10(-9)M)加入培养基中,使标记指数节律的周期从20.36小时移至23.48小时。褪黑激素显着​​增加(p <0.005)人类乳腺癌细胞周期的事实支持这一观点,即该激素通过延迟MCF-进入细胞周期特异性机制,发挥其部分抗肿瘤作用。 7细胞进入有丝分裂。 [参考:31]

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