SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL PROFILE OF TROPICAMIDE ENANTIOMERS

Dei S.; Ghelardini C.; Romanelli MN.; Spampinato S.; Bellucci C.

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SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL PROFILE OF TROPICAMIDE ENANTIOMERS

机译：对乙酰氨基化物对映体的合成，表征和药理学特征

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The synthesis, chemical characterization and antimuscarinic activity of the two enantiomers of tropicamide are reported. Functional (rabbit vas deferens, guinea pig heart (force) and ileum) as well as binding experiments (m(1) and m(4) human muscarinic receptors expressed in CHO-K1 cells; M(2) and M(3) receptors of rat heart and submaxillary gland membranes) were used to evaluate the antimuscarinic activity of the enantiomers. The results show that none of the enantiomers is able to significantly discriminate among the receptors studied and therefore do not support the proposal of tropicamide as an M(4) (m(4)) selective agent. [References: 27]

机译：报道了托吡酰胺的两种对映异构体的合成，化学表征和抗毒蕈碱活性。功能性（兔输精管，豚鼠心脏（力）和回肠）以及结合实验（在CHO-K1细胞中表达的人毒蕈碱受体（m（1）和m（4））; M（2）和M（3）受体（大鼠心脏和上颌下腺膜的抗性）用于评估对映异构体的抗毒蕈碱活性。结果表明，没有一种对映异构体能够明显区分所研究的受体，因此不支持将tropicamide作为M（4）（m（4））选择剂的提议。 [参考：27]

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《Life sciences》 |1996年第23期|共7页
作者
Dei S.; Ghelardini C.; Romanelli MN.; Spampinato S.; Bellucci C.;
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正文语种 eng
中图分类生命的起源;生命科学总论;
关键词
Tropicamide enantiomers; M(4) selective muscarinic antagonist; M(1)-m(4) subtypes; Analgesia; Muscarinic receptor subtypes; Binding-sites; Antagonist; Rat;

机译：Tropicamide对映异构体;M（4）选择性毒蕈碱拮抗剂;M（1）-m（4）亚型;镇痛;毒蕈碱受体亚型;结合位点;拮抗剂;大鼠;

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1. SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL PROFILE OF TROPICAMIDE ENANTIOMERS [J] . Dei S., Ghelardini C., Romanelli MN., Life sciences . 1996,第23期

机译：对乙酰氨基化物对映体的合成，表征和药理学特征
2. Synthesis, characterization, and crystal structure of RNA targeted L- and D-phenylalanine-(1,10-phen)-copper(II) conjugate complexes: comparative in vitro RNA binding profile of enantiomers and their biological evaluation by morphological studies and antibacterial activity [J] . Sharma Surbhi, Toupet Loic, Ahmad Musheer, RSC Advances . 2016,第83期

机译：RNA靶向L-和D-苯丙氨酸 - （1,10-苯甲丙氨酸 - （II）缀合物复合物的合成，表征和晶体结构：对映异构体的比较体外RNA结合谱及其形态学研究的生物学评价及抗菌活性
3. Synthesis, characterization, and crystal structure of RNA targeted l- and d-phenylalanine-(1,10-phen)–copper(ii) conjugate complexes: comparative in vitro RNA binding profile of enantiomers and their biological evaluation by morphological studies and antibacterial activity [J] . Surbhi Sharma, Loic Toupet, Musheer Ahmad, RSC Advances . 2016,第83期

机译：RNA靶向L-和D-苯丙氨酸 - （1,10-苯甲丙氨酸 - （II）缀合物复合物的合成，表征和晶体结构：对映异构体的比较体外RNA结合谱及其形态学研究的生物学评价及抗菌活性
4. Synthesis and in vitro Pharmacological Profile of Potent and Selective Peptidic V1a Receptor Agonists. [C] . Kazinlierz Wisniewski, Robert Galyean, Hiroe Taki American Peptide Symposium . 2009

机译：效力和选择性肽V1A受体激动剂的合成与体外药理学谱。
5. Part I: Synthesis and structural characterization of some transition metal complexes derived from Schiff base ligands Part II: Crystallographic studies of pharmacologically active compounds. [D] . Assey, Gervas E. 2010

机译：第一部分：席夫碱配体衍生的某些过渡金属配合物的合成和结构表征第二部分：药理活性化合物的晶体学研究。
6. Scalable Preparation and Differential Pharmacologic and Toxicologic Profiles of Primaquine Enantiomers [O] . N. P. Dhammika Nanayakkara, Babu L. Tekwani, H. M. T. Bandara Herath, 2014

机译：伯氨喹对映异构体的可扩展制备及药理和毒理学差异
7. Scalable Preparation and Differential Pharmacologic and Toxicologic Profiles of Primaquine Enantiomers [O] . Dhammika Nanayakkara N. P., Tekwani Babu L., Bandara Herath H. M. T., 2016

机译：伯氨喹对映异构体的可扩展制备及药理和毒理学差异
8. Characterization of the Chemical Constitution and Profile of Pharmacological Activity of PGB(x). [R] . Burkman, A. M., Doskotch, R. W., Miller, D. D. 1983

机译：pGB（x）的化学组成和药理活性特征的表征。

SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL PROFILE OF TROPICAMIDE ENANTIOMERS

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