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首页> 外文期刊>Life sciences >SLEEP INDUCTION BY MICROINJECTION OF PENTOBARBITAL INTO THE MEDIAL PREOPTIC AREA IN RATS [Review]
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SLEEP INDUCTION BY MICROINJECTION OF PENTOBARBITAL INTO THE MEDIAL PREOPTIC AREA IN RATS [Review]

机译：通过微注射五溴代苯进入大鼠视前内侧区域引起的睡眠[综述]

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摘要

In a previous study we have shown that microinjection of the benzodiazepine hypnotic triazolam into the medial preoptic area increases sleep in rats. In order to determine whether this effect is specific to benzodiazepines, or whether it occurs with hypnotic medications from other pharmacologic classes, we have microinjected pentobarbital (1 and 100 ug) and vehicle in random sequence into rats and performed two hour sleep studies in the daytime with the lights on. Both doses significantly decreased sleep latency and increased nonREM and total sleep. The amount of REM sleep, REM latency, and intermittent waking time were not significantly altered. These data are consistent with the hypothesis that the medial preoptic area may be involved in sleep induction by both benzodiazepine and barbiturate hypnotic medications. [References: 28]
机译：在先前的研究中，我们显示了将苯二氮卓类催眠三唑仑微注射入视前内侧区域可增加大鼠的睡眠。为了确定这种作用是否对苯二氮卓类药物特异，还是与其他药理学类的催眠药一起发生，我们将戊巴比妥（1和100 ug）和赋形剂随机注射到大鼠中，并在白天进行了两个小时的睡眠研究灯亮着。两种剂量均可显着降低睡眠潜伏期，并增加非快速眼动和总睡眠时间。 REM睡眠量，REM潜伏期和间歇性清醒时间没有明显改变。这些数据与以下假设相吻合，即：视光前内侧区域可能与苯二氮卓类药物和巴比妥类催眠药同时诱发睡眠。 [参考：28]

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