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首页> 外文期刊>Life sciences >Relationship between cocaine-induced hepatotoxic neurobehavioral & biochemical changes in mice: the antidotal effects of buprenorphine.
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Relationship between cocaine-induced hepatotoxic neurobehavioral & biochemical changes in mice: the antidotal effects of buprenorphine.

机译：可卡因诱导的小鼠肝毒性神经行为与生化变化之间的关系：丁丙诺啡的解毒作用。

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摘要

Cocaine (COCA)-induced neurobehavioral symptoms, which can be observed simultaneously with exacerbation in biochemical markers, were evaluated in mice, and compared with the changes observed in a representative hepatic failure model induced by thioacetamide (TAA). The effects of pretreatment with buprenorphine (BUP) (0.25, 0.5 or 1 mg/kg i.p.), a mixed opioid agonist-antagonist and an antidote against fatal COCA toxicity, were also examined. At 5 min after the COCA administration (65 mg/kg i.p.), the liver ATP levels were attenuated, and an exacerbation of the CNS-stimulating effects of COCA could be characteristically observed for hepatotoxicity-related neurobehavioral symptoms (changes in alertness, interest, body tension, head movement and walking). At 24 h, the ALT (alanine aminotransferase) activity was elevated, and hepatotoxic attenuation was observed for all of the scores on the neurobehavioral symptoms; this was almost identical to the symptoms observed in the TAA-treated group of mice. Recovery was observed by 72 h for all of the morbid changes. The hepatotoxic biochemical changes and the sum score for all five neurobehavioral symptoms were significantly ameliorated by low doses (0.25 and 0.5 mg/kg) of BUP, both at 5 min and 24 h.
机译：在小鼠中评估了可卡因（COCA）诱导的神经行为症状，该现象可在生化标记加剧的同时观察到，并与由硫代乙酰胺（TAA）诱导的代表性肝衰竭模型中观察到的变化进行比较。还检查了丁丙诺啡（BUP）（0.25、0.5或1 mg / kg i.p.），混合阿片类激动剂-拮抗剂和抗致命COCA毒性的解毒剂预处理的效果。给予COCA后5分钟（65 mg / kg腹膜内），肝脏ATP水平降低，并且可以观察到肝毒性相关的神经行为症状（警觉性，兴趣，身体紧张，头部运动和行走）。在24小时时，ALT（丙氨酸转氨酶）活性升高，并且在神经行为症状的所有评分中均观察到肝毒性减弱。这几乎与在TAA治疗组的小鼠中观察到的症状相同。所有病态变化均在72 h时恢复。低剂量（0.25和0.5 mg / kg）的BUP分别在5分钟和24 h时，可明显改善所有五个神经行为症状的肝毒性生化变化和总分。

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