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首页> 外文期刊>Cell biology international. >Growing evidence of the repopulation of regressed tumours by the division of giant cells
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Growing evidence of the repopulation of regressed tumours by the division of giant cells

机译：越来越多的证据表明巨细胞分裂会消退肿瘤

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It has long been supposed that giant cells that arise by en-doreduplication (polyploidy) and/or incomplete cytokinesis (multinucleation) have no future. Although giant cells can survive a remarkably long period of time, any attempt to "move on" in the cell cycle has generally been seen as suicidal, resulting in a "mitotic catastrophe". The evidence to support this is incontrovertible. However, over the last few years, several groups have independently shown that, while most giant cells do succumb in time, it is not true in all cases. Experimental evidence has emerged that clearly shows giant cells undergoing a form of reduction from which small cells with a quasi-diploid or para-diploid chromosome complement are among the "progeny" that have the properties of the rapidly proliferating pool of cell that first gave rise to the tumour.
机译：长期以来人们一直认为，通过核复制（多倍性）和/或不完全的胞质分裂（多核化）产生的巨细胞没有未来。尽管巨细胞可以存活很长的时间，但是通常认为在细胞周期中“继续前进”的任何企图都是自杀的，从而导致“有丝分裂灾难”。支持这一点的证据是无可争议的。然而，在过去几年中，几个小组独立地表明，尽管大多数巨型细胞确实会及时屈服，但并非在所有情况下都是如此。实验证据已经出现，清楚地表明巨细胞正在经历某种形式的还原，具有准二倍体或准二倍体染色体补体的小细胞是具有“细胞后代”特性的“后代”之一。到肿瘤。

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