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首页> 外文期刊>Life sciences >Melatonin reduces oxidative damage to skin and normalizes blood coagulation in a rat model of thermal injury.
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Melatonin reduces oxidative damage to skin and normalizes blood coagulation in a rat model of thermal injury.

机译：褪黑素可减少热损伤大鼠模型对皮肤的氧化损伤并使血液凝固正常化。

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This study was designed to determine the effect of melatonin treatment on the glutathione (GSH) and lipid peroxidation (LPO) levels in the skin as well as prothrombin time (PT) and fibrin degradation products (FDPs) in the blood of rats with thermal injury. Under ether anaesthesia, the shaved dorsum of the rats was exposed to 90 degrees C bath for 10 s to induce burn injury. Rats were decapitated either 3 or 24 hours after burn injury. Melatonin (10 mg/kg) was administered i.p. immediately after burn injury to same animals. In the 24 hour burn group, melatonin injections were repeated for two more occasions 8 and 16 h after burn injury. In the control group the same protocol was applied except that the dorsum was exposed to a 25 degrees C water bath for 10 s. Severe skin scald injury (30% of total body surface area) caused a significant decrease in PT at post burn 3 and 24 hours. FDPs was not increased at post burn 3 hour but was significantly increased at post burn 24 hour. GSH levels were significantly depressed at post burn 3 hour but were not changed at post burn 24 hour. LPO levels were significantly increased both at post burn 3 and 24 hours. Skin protein levels were significantly reduced at post burn 24 hour as evidenced by electrophoresis. Treatment of rats with melatonin normalized PT levels both at post burn 3 and 24 hours. FDP decreased at post burn 24 hour due to melatonin treatment. GSH levels significantly increased as a result of melatonin treatment both at post burn 3 and 24 hours melatonin treatment. LPO levels were not changed by melatonin at post burn 3 hour; however, the melatonin significantly decreased LPO values at post burn 24 hours. In conclusion, exogenously administered melatonin reduced skin oxidant damage and normalized the activated blood coagulation induced by thermal trauma.
机译：这项研究旨在确定褪黑素治疗对热损伤大鼠血液中谷胱甘肽（GSH）和脂质过氧化（LPO）水平以及凝血酶原时间（PT）和纤维蛋白降解产物（FDPs）的影响。在乙醚麻醉下，将大鼠剃毛的背部暴露于90°C的浴中10秒钟，以引起烧伤。烧伤后3或24小时将大鼠断头。腹膜内注射褪黑激素（10 mg / kg）。烧伤后立即对同一只动物造成伤害。在24小时烧伤组中，烧伤后分别在8和16 h再次注射褪黑激素两次。在对照组中，除了将背部暴露于25摄氏度的水浴中10秒钟外，均采用相同的方案。严重的皮肤烫伤（占全身表面积的30％）导致烧伤后3和24小时的PT显着下降。烧伤后3小时FDP并未增加，但烧伤后24小时则显着增加。烧伤后3小时GSH水平显着降低，但烧伤后24小时未改变。烧伤后3小时和24小时，LPO水平均显着升高。电泳表明，烧伤后24小时皮肤蛋白质水平显着降低。褪黑素治疗大鼠在烧伤后3小时和24小时均恢复了PT水平。由于褪黑激素治疗，烧伤后24小时FDP降低。褪黑素治疗在烧伤后3小时和24小时均因褪黑激素治疗而使GSH水平显着升高。烧伤后3小时褪黑激素不会改变LPO水平;然而，褪黑激素在烧伤后24小时显着降低LPO值。总之，外源性褪黑激素可减少皮肤氧化剂的损害并使热损伤引起的活化凝血正常化。

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