Carbenoxolone, a new inducer of heat shock protein 70.

Nagayama S; Jono H; Suzaki H; Sakai K; Tsuruya E; Yamatsu I; Isohama Y; Miyata T; Kai H

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Carbenoxolone, a new inducer of heat shock protein 70.

机译：Carbenoxolone，一种新的热休克蛋白70诱导剂。

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Heat shock protein 70 (Hsp70) is capable of protecting cells, tissues, organs, and animals from a subsequent, normally lethal heating, as well as from numerous disease states. Therefore, it would be of great therapeutic benefit to discover compounds that are clinically safe yet able to induce Hsp70 in patients. Carbenoxolone, an antiulcer drug, protects gastric mucosal cells against irritants in vivo and in vitro. We assessed here whether carbenoxolone induces Hsp70 expression in human cell lines. We found that carbenoxolone increased the expression of Hsp70 protein and mRNA, and Hsp70 promoter activity.

机译：热休克蛋白70（Hsp70）能够保护细胞，组织，器官和动物免受随后通常致命的加热以及多种疾病的侵害。因此，发现在临床上安全但能够在患者中诱导Hsp70的化合物将具有巨大的治疗益处。 Carbenoxolone是一种抗溃疡药，可在体内和体外保护胃粘膜细胞免受刺激。我们在这里评估了羧苄酮是否能在人细胞系中诱导Hsp70表达。我们发现，羧苄酮可增加Hsp70蛋白和mRNA的表达以及Hsp70启动子的活性。

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《Life sciences》 |2001年第24期|共7页
作者
Nagayama S; Jono H; Suzaki H; Sakai K; Tsuruya E; Yamatsu I; Isohama Y; Miyata T; Kai H;
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正文语种 eng
中图分类基础医学;
关键词
Anti-Ulcer Agents; Carbenoxolone; HSP70 Heat-Shock Proteins; 抗溃疡病药; 甘珀酸;

机译：Anti-Ulcer Agents;Carbenoxolone;HSP70 Heat-Shock Proteins;抗溃疡病药;甘珀酸;

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1. Carbenoxolone, a new inducer of heat shock protein 70. [J] . Nagayama S, Jono H, Suzaki H, Life sciences . 2001,第24期

机译：Carbenoxolone，一种新的热休克蛋白70诱导剂。
2. Cardioprotection by CaMKII-deltaB is mediated by phosphorylation of heat shock factor 1 and subsequent expression of inducible heat shock protein 70. [J] . Peng W, Zhang Y, Zheng Circulation research: a journal of the American Heart Association . 2010,第1期

机译：CaMKII-deltaB的心脏保护作用是由热激因子1的磷酸化和随后诱导型热激蛋白70的表达介导的。
3. The maximal cytoprotective function of the heat shock protein 27 is dependent on heat shock protein 70. [J] . Sreedharan R, Riordan M, Thullin G, Biochimica et biophysica acta. Molecular cell research . 2011,第1期

机译：热激蛋白27的最大细胞保护功能取决于热激蛋白70。
4. Mining Heat Stress Induced Genes Encoding Heat Shock Proteins (HSPs) and Heat Stress Transcription Factors (HSFs) in Strawberry (Fragaria x ananassa) [C] . Lee-Fong Lin, Shih-Yi Liao, Jui-Hung Yen, International Conference on Mechanics and Control Engineering . 2014

机译：采矿热应激诱导在草莓（Fragaria x ananassa）中编码热休克蛋白（HSP）和热应激转录因子（HSF）的热应激诱导基因
5. Dendritic cell-based cancer vaccines using adenovirally mediated expression of the HER-2/neu gene and apoptotic tumor cells expressing heat shock protein 70. [D] . Chan, Tim. 2006

机译：使用HER-2 / neu基因的腺病毒介导表达和表达热休克蛋白70的凋亡肿瘤细胞的基于树突细胞的癌症疫苗。
6. Protection against myocardial dysfunction after a brief ischemic period in transgenic mice expressing inducible heat shock protein 70. [O] . S U Trost, J H Omens, W J Karlon, 1998

机译：在短暂的缺血期后表达诱导型热休克蛋白70的转基因小鼠对心肌功能障碍的保护作用。
7. Carbenoxolone Could Deteriorate Streptozotocin-induced Diabetes through Induction of Heat Shock Protein 70 and IFN-γ in C57BL/6 Mice [O] . Mehdi Rasouli, Yaser Jafari-khataylou, Javad Ashrafi-Helan 2019

机译：通过在C57BL / 6小鼠中诱导热休克蛋白70和IFN-γ来促进链蛋白毒素诱导的链脲素蛋白诱导的糖尿病
8. Expression and Function of Heat Shock Proteins in the Mammalian Gut During Experimentally Induced Hypoxia and Exogenous Stress [R] . Murashov, A. K. 1999

机译：热休克蛋白在哺乳动物肠道实验性缺氧和外源性应激过程中的表达和功能

Carbenoxolone, a new inducer of heat shock protein 70.

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