A reduction of tumor necrosis factor-alpha in paw exudate of lipopolysaccharide treated rats by nimesulide.

Azab AN; Kaplanski J

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A reduction of tumor necrosis factor-alpha in paw exudate of lipopolysaccharide treated rats by nimesulide.

机译：尼美舒利降低脂多糖处理大鼠足爪分泌物中的肿瘤坏死因子-α。

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TNF-alpha is considered to play a pivotal role in many inflammatory and illness states. In our previous study we found that nimesulide, a COX-2 selective inhibitor, prevents the lipopolysaccharide-induced elevation in plasma TNF-alpha in rats. The present study was undertaken to elucidate the effect of nimesulide on TNF-alpha levels in the paw exudate of rats pretreated with lipopolysaccharide (LPS). Rats were injected (subplantar) with LPS (100 microg/paw) in the right hind, which resulted in a prominent increase in paw exudate TNF-alpha levels, peaked at one hour post injection. In rats pretreated with nimesulide (30 mg/kg, i.p.), the elevation in TNF-alpha in the paw exudate was significantly reduced, as compared to the LPS treated group. These results further stress the multiple antiinflammatory effects of nimesulide.

机译：TNF-α被认为在许多炎症和疾病状态中起关键作用。在我们之前的研究中，我们发现尼美舒利是一种COX-2选择性抑制剂，可预防脂多糖诱导的大鼠血浆TNF-α升高。进行本研究以阐明尼美舒利对用脂多糖（LPS）预处理的大鼠爪渗出液中TNF-α水平的影响。大鼠在右后方注射（足底）LPS（100微克/爪），导致爪渗出液TNF-α水平显着增加，在注射后一小时达到峰值。与LPS治疗组相比，在用尼美舒利（30 mg / kg，i.p.）预处理的大鼠中，爪分泌液中TNF-α的升高明显降低。这些结果进一步强调了尼美舒利的多种抗炎作用。

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《Life sciences》 |2001年第14期|共9页
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Azab AN; Kaplanski J;
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正文语种 eng
中图分类生命的起源;生命科学总论;
关键词
Anti-Inflammatory Agents; Non-Steroidal; Exudates and Transudates; Lipopolysaccharides; 消炎药; 非甾类; 渗出液和滤出液; 脂多糖类; 磺胺类; 肿瘤坏死因子;

机译：Anti-Inflammatory Agents;Non-Steroidal;Exudates and Transudates;Lipopolysaccharides;消炎药;非甾类;渗出液和滤出液;脂多糖类;磺胺类;肿瘤坏死因子;

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1. A reduction of tumor necrosis factor-alpha in paw exudate of lipopolysaccharide treated rats by nimesulide. [J] . Azab AN, Kaplanski J Life sciences . 2001,第14期

机译：尼美舒利降低脂多糖处理大鼠足爪分泌物中的肿瘤坏死因子-α。
2. Shiga Toxin 1 Induces on Lipopolysaccharide-Treated Astrocytes the Release of Tumor Necrosis Factor-alpha that Alter Brain-Like Endothelium Integrity [J] . Cecilia Calatayud, Gabriela C. Fernández, Marcelo de Campos Nebel, PLoS Pathogens . 2012,第3期

机译：志贺毒素1诱导脂多糖处理的星形胶质细胞释放肿瘤坏死因子-α的改变，改变大脑样内皮素的完整性。
3. Effect of 17-alpha hydroxyprogesterone caproate on the production of tumor necrosis factor-alpha and the expression of cyclooxygenase-2 in lipopolysaccharide-treated gravid human myometrial explants. [J] . Patel S, Li A, Goodwin TM, Journal of perinatology: Official journal of the California Perinatal Association . 2010,第9期

机译：己酸17-α羟孕酮对脂多糖处理的妊娠人肌子宫外植体中肿瘤坏死因子-α的产生和环氧合酶-2表达的影响。
4. A Novel Humanized Single-Chain Variable-Fragment Antibody Against the Tumor Necrosis Factor-Alpha [C] . Davoud Farajzadeh, Siavoush Dastmalchi PEGS . 2014

机译：对肿瘤坏死因子-α的新型人源化单链可变片段抗体
5. A distinct element involved in the lipopolysaccharide activation of the tumor necrosis factor-alpha promoter in a promonocytic cell line, THP-1. [D] . Diaz, Belisa. 1999

机译：在原单核细胞系THP-1中，与肿瘤坏死因子-α启动子的脂多糖活化有关的独特元素。
6. Shiga Toxin 1 Induces on Lipopolysaccharide-Treated Astrocytes the Release of Tumor Necrosis Factor-alpha that Alter Brain-Like Endothelium Integrity [O] . Verónica I. Landoni, Pablo Schierloh, Marcelo de Campos Nebel, 2012

机译：志贺毒素1诱导脂多糖处理的星形胶质细胞释放肿瘤坏死因子-α的释放改变大脑样内皮素的完整性。
7. Shiga Toxin 1 Induces on Lipopolysaccharide-Treated Astrocytes the Release of Tumor Necrosis Factor-alpha that Alter Brain-Like Endothelium Integrity [O] . Landoni, Verónica I., Schierloh, Pablo, de Campos Nebel, Marcelo, 2012

机译：志贺毒素1诱导脂多糖处理的星形胶质细胞释放肿瘤坏死因子-α的释放，改变大脑样内皮素的完整性。

A reduction of tumor necrosis factor-alpha in paw exudate of lipopolysaccharide treated rats by nimesulide.

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