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首页> 外文期刊>Life sciences >Effect of human and murine interferon-alpha on steroid production by rat ovarian cells.
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Effect of human and murine interferon-alpha on steroid production by rat ovarian cells.

机译：人和鼠干扰素-α对大鼠卵巢细胞类固醇产生的影响。

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摘要

The effect of interferon on the rat ovarian cell function was investigated. Cells from the ovary of juvenile rats were used as a model to investigate the effect of IFN-alpha on the secretion of estradiol and testosterone. In addition the effect of human IFN-alpha (hIFN-alpha) on the secretion of testosterone by the rat adult testis was studied. Present results show that leukocyte hIFN-alpha decreased the human chorionic gonadotropin (hCG) stimulated secretion of estradiol and testosterone by ovarian cells, and the production of testosterone by testis cells. Basal secretion of steroids was affected later and in less proportion than the hCG-dependent production. The IFN-alpha obtained from murine leukocytes, also inhibited the response of ovarian cells to the hCG stimulus.The nature of this effect in the secretion of the steroids is dose and time-dependent. The incubation of hIFN-alpha with an specific antibody completely blocked the effect of the cytokine on ovarian cells.
机译：研究了干扰素对大鼠卵巢细胞功能的影响。以幼鼠卵巢细胞为模型，研究IFN-α对雌二醇和睾丸激素分泌的影响。另外，研究了人IFN-α（hIFN-α）对大鼠成年睾丸分泌睾丸激素的影响。目前的结果表明，白细胞hIFN-α降低了人绒毛膜促性腺激素（hCG）刺激的卵巢细胞分泌雌二醇和睾丸激素，以及睾丸细胞产生的睾丸激素。类固醇的基础分泌受到的影响比hCG依赖的生产晚，且比例较小。从鼠白细胞中获得的IFN-α也抑制了卵巢细胞对hCG刺激的反应。这种作用在类固醇分泌中的性质是剂量和时间依赖性。 hIFN-α与特异性抗体的孵育完全阻断了细胞因子对卵巢细胞的作用。

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