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首页> 外文期刊>Life sciences >OSTEOPENIA IN GENETICALLY DIABETIC DB/DB MICE AND EFFECTS OF 1-ALPHA-HYDROXYVITAMIN D3 ON THE OSTEOPENIA
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OSTEOPENIA IN GENETICALLY DIABETIC DB/DB MICE AND EFFECTS OF 1-ALPHA-HYDROXYVITAMIN D3 ON THE OSTEOPENIA

机译：遗传性糖尿病DB / DB小鼠中的骨质疏松症和1-α-羟基维生素D3对骨质疏松症的影响

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To explore the pathogenesis of non-insulin-dependent diabetes mellitus associated osteopenia, we examined age-related changes of the femur metaphyseal bone mineral density in genetically diabetic (db/db) mice and non-diabetic (+/+) mice of the same strain using single photon absorptiometry and characterized the osteopenia pharmacologically and biochemically. Bone mineral density increased with age in the +/+ mice from 5 to 16 weeks of age, but reached a plateau in the db/db mice at 8 weeks of age, and significant differences between the two groups were observed after 12 weeks of age. Ash weight (A) and dry weight (D) of the femur and A/D ratio were significant lower in the db/db mice than in the +/+ mice after 8 weeks of age. Significant elevations of serum calcium and parathyroid hormone (PTH) were observed after 8 weeks and 12 weeks of age, respectively. Serum 1 alpha,25-dihydroxyvitamin D levels were significantly decreased in the db/db mice compared to the +/+ mice. Daily oral treatment with 1 alpha-hydroxyvitamin D3 (1 alpha-(OH)D3) for 4 weeks starting from 8 weeks of age significantly attenuated the bone loss in the db/db mice. These results suggest that an impaired bone mineralization probably by insufficient vitamin D activity and high PTH levels are involved in the osteopenia in the db/db mice. 1 alpha-(OH)D3 exerted beneficial effects on the bone loss. [References: 25]
机译：为了探讨非胰岛素依赖型糖尿病相关骨质减少的发病机制，我们检查了同一基因的糖尿病（db / db）小鼠和非糖尿病（+ / +）小鼠的股骨干phy端骨矿物质密度的年龄相关变化使用单光子吸收法测定菌株，并在药理和生化方面表征骨质减少。在5至16周龄的+ / +小鼠中，骨矿物质密度随年龄增加而增加，但在8周龄的db / db小鼠中骨矿物质密度达到稳定，并且在12周龄后观察到两组之间的显着差异。 db / db小鼠的骨灰分（A）和干重（D）以及A / D比在8周龄后明显低于+ / +小鼠。分别在8周和12周龄后观察到血清钙和甲状旁腺激素（PTH）明显升高。与+ / +小鼠相比，db / db小鼠的血清1α，25-二羟基维生素D水平显着降低。从8周龄开始，每天口服1种α-羟基维生素D3（1α-（OH）D3）持续4周，可显着减轻db / db小鼠的骨质流失。这些结果表明，db / db小鼠的骨质疏松症可能是由于维生素D活性不足和高PTH水平导致的骨矿化受损。 1α-（OH）D3对骨质流失具有有益作用。 [参考：25]

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