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首页> 外文期刊>Life sciences >Effects of chronic treatment with ipsapirone and buspirone on the C57BL/6J strain mice under social stress.
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Effects of chronic treatment with ipsapirone and buspirone on the C57BL/6J strain mice under social stress.

机译：ipsapirone和buspirone长期治疗对社会压力下C57BL / 6J品系小鼠的影响。

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摘要

We experimented on inbred C57BL/6J strain mice who experienced social stress caused by defeat in inter-male confrontations for 20 days. From the fifth fight on, some mice were injected with ipsapirone (3 mg/kg), and some with buspirone (1 mg/kg) on a daily basis, for 14 days. Post-treatment behavior was examined in the plus-maze, partition, and Porsolt forced swim test (Porsolt's test). Each of these drugs had anxiolytic effects in the plus-maze, suggesting that they reduce state anxiety. Neither had any effect in the partition test, which provides further support to the hypothesis that normally the C57BL/6J strain mice have a high level of trait anxiety and for that reason they did not respond to the drugs. Chronic treatment with neither drug had any effect in the Porsolt's test. It is proposed that ipsapirone and buspirone fail to alleviate the depressive-like behaviors in the C57BL/6J mice because of a high level of trait anxiety, which might be inherent to this mouse strain.
机译：我们对近交C57BL / 6J品系小鼠进行了实验，这些小鼠经历了由男性间对抗失败导致的社会压力，持续了20天。从第五次战斗开始，每天向小鼠注射ipsapirone（3 mg / kg），向另一些小鼠注射丁螺环酮（1 mg / kg），持续14天。在正迷宫，分隔和Porsolt强迫游泳测试（Porsolt's test）中检查了治疗后的行为。这些药物中的每一种在迷宫中均具有抗焦虑作用，表明它们可减轻状态焦虑。二者均未在分区试验中产生任何作用，这进一步支持了以下假设：正常C57BL / 6J品系小鼠具有高水平的性状焦虑，因此，它们对药物没有反应。两种药物的长期治疗对Porsolt检验均无影响。有人提出，由于高水平的特质焦虑，ipsapirone和buspirone不能减轻C57BL / 6J小鼠的抑郁样行为，这可能是该小鼠品系固有的。

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