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5-HT1A receptor blockade and the motivational profile of ethanol.

机译：5-HT1A受体阻滞和乙醇的动机特征。

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摘要

Although several serotonin (5-HT) receptor subtypes influence ethanol consumption, the motivational mechanisms underlying these changes remain unclear. The present experiments characterized the rewarding, aversive and stimulant effects of ethanol in combination with a specific 5-HT1A receptor antagonist (pindobind-5HT1A). In a place conditioning study, adult male Swiss-Webster mice received 6 parings of a distinctive tactile stimulus with either 2 g/kg ethanol, 2.5 mg/kg pindobind-5HT1A, or both drugs in combination. Ethanol-conditioned preference for the tactile cue was enhanced in mice also receiving pindobind-5HT1A, which did not produce cue preference in the absence of ethanol. In a taste conditioning study, Swiss-Webster mice received 4 trials consisting of access to a distinctive NaCl flavor followed by either 4 g/kg ethanol, 2.5 mg/kg pindobind-5HT1A, or both drugs. As expected, ethanol produced avoidance of the flavor. Pindobind-5HT1A did not reduce or enhance ethanol-conditioned flavor aversion. In a study characterizing locomotor activity, 2 g/kg ethanol produced stimulation, which was enhanced after 10 daily treatments. Locomotor sensitization was not altered by co-treatment with pindobind-5HT1A. Overall, the present results show specific effects of 5-HT1A blockade on ethanol reward.
机译：尽管几种血清素（5-HT）受体亚型会影响乙醇的消耗，但这些变化背后的动机机制仍不清楚。本实验表征了乙醇与特定的5-HT1A受体拮抗剂（pindobind-5HT1A）结合产生的有益，厌恶和刺激作用。在一项场所条件研究中，成年雄性Swiss-Webster小鼠接受了6对配对的特殊触觉刺激，其中包含2 g / kg乙醇，2.5 mg / kg pindobind-5HT1A或两种药物的组合。在接受pindobind-5HT1A的小鼠中，乙醇对触觉提示的偏爱也得到了增强，而在没有乙醇的情况下，它们不会产生提示偏爱。在一项味觉调节研究中，Swiss-Webster小鼠接受了4个试验，包括获得独特的NaCl风味，然后使用4 g / kg乙醇，2.5 mg / kg pindobind-5HT1A或两种药物。如预期的那样，乙醇避免了风味。 Pindobind-5HT1A不会减少或增强乙醇调节的风味厌恶。在一项表征运动活性的研究中，2 g / kg乙醇产生刺激，在每天10次治疗后，刺激得到增强。与pindobind-5HT1A共同治疗不会改变运动敏化度。总的来说，目前的结果表明5-HT1A阻断对乙醇奖赏的特定作用。

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