首页> 外文期刊>Life sciences >Lowered serum n-3 polyunsaturated fatty acid (PUFA) levels predict the occurrence of postpartum depression: Further evidence that lowered n-PUFAs are related to major depression.
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Lowered serum n-3 polyunsaturated fatty acid (PUFA) levels predict the occurrence of postpartum depression: Further evidence that lowered n-PUFAs are related to major depression.

机译:较低的血清n-3多不饱和脂肪酸(PUFA)水平可预测产后抑郁症的发生:进一步的证据表明,较低的n-PUFAs与严重抑郁症有关。

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Several studies have shown that major depression is accompanied by alterations in serum fatty acid composition, e.g. reduced n-3 fatty acids and an increased 20:4n-6/20:5n-3 ratio in serum. Moreover, pregnancy leads to depletion of maternal serum 22:6n-3 and after delivery maternal serum 22:6n-3 steadily declines further. Therefore, the aim of the present study was to investigate whether the postpartum fatty acid profile of maternal serum phospholipids (PL) and cholesteryl esters (CE) differs in women who develop postpartum depression compared to controls. We compared the fatty acid composition shortly after delivery of 10 women who developed postpartum depression and 38 women who did not. After delivery, 22:6n-3 and the sum of the n-3 fatty acids in PL and CE was significantly lower in the group of mothers who developed a postpartum depression. The ratio of Sigman-6/Sigman-3 fatty acids in PL was, postpartum, significantly higher in the depressed group as compared to the controls. The abnormalities infatty acid status previously observed in major depression are now also confirmed in postpartum depression. These results indicate that pregnant women who are at risk to develop postpartum depression may benefit from a prophylactic treatment with n-3 PUFAs, such as a combination of 20:5n-3 and 22:6n-3.
机译:几项研究表明,严重的抑郁症伴随着血清脂肪酸组成的改变,如降低n-3脂肪酸含量,并提高血清中20:4n-6 / 20:5n-3比例。此外,怀孕导致母体血清22:6n-3消耗and尽,分娩后母体血清22:6n-3稳定下降。因此,本研究的目的是调查与对照组相比,产后抑郁症妇女的孕妇血清磷脂(PL)和胆固醇酯(CE)的产后脂肪酸谱是否不同。我们比较了分娩后不久有10例产后抑郁症的妇女和38例没有产后抑郁症的妇女的脂肪酸组成。分娩后,在产后抑郁症的母亲群体中,PL和CE中22:6n-3和n-3脂肪酸的总和显着降低。与对照组相比,抑郁组的产后PL中Sigman-6 / Sigman-3脂肪酸的比例明显更高。以前在重度抑郁症中观察到的脂肪酸状态异常现在也已在产后抑郁症中得到证实。这些结果表明,有发生产后抑郁症风险的孕妇可能会受益于n-3 PUFA的预防性治疗,例如20:5n-3和22:6n-3的联合治疗。

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